An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors
Abstract
:1. Introduction
2. Structure of the nAChR Intracellular Domain
3. Postsynaptic Localization of the Muscle nAChR
3.1. AChR Localization Is Mediated by Rapsyn
3.2. AChR-Rapsyn Stoichiometry
3.3. The nAChR-Rapsyn Binding Sites
3.4. Function of nAChR-Rapsyn Interactions
4. Postsynaptic Localization of Neuronal nAChRs
Determinants for Neuronal nAChR Localization
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
APC | adenomatous polyposis coli |
CNS | central nervous system |
CMS | congenital myasthenic syndrome |
ICD | intracellular domain |
nAChR | nicotinic acetylcholine receptor |
NMJ | neuromuscular junction |
PNS | peripheral nervous system |
PM | plasma membrane |
TM | transmembrane |
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Ferns, M. An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors. Molecules 2021, 26, 3065. https://doi.org/10.3390/molecules26113065
Ferns M. An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors. Molecules. 2021; 26(11):3065. https://doi.org/10.3390/molecules26113065
Chicago/Turabian StyleFerns, Michael. 2021. "An Inside Job: Molecular Determinants for Postsynaptic Localization of Nicotinic Acetylcholine Receptors" Molecules 26, no. 11: 3065. https://doi.org/10.3390/molecules26113065