Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3
Abstract
:1. Introduction
2. Classification of Wounds
3. Wound-Healing Process
3.1. Hemostasis Phase
3.2. Inflammation Phase
3.3. Proliferation Phase
3.4. Remodeling Phase
4. Wound Dressings
5. Biological Activity of Rg3
6. Application of Ginsenoside Rg3 in Wound-Healing Course
7. Rg3-Loaded Wound Dressing
7.1. Hydrogels
7.2. Nanofibers
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Serial Number | Dressing Type | Composition | Animal Model | Molecular Mechanism | Reference |
---|---|---|---|---|---|
1 | hydrogel | Methoxy poly(ethylene glycol) (PEG); D,L-lactide (D,L-LA); glycolide (GA) | perianal ulcer in rats | Decrease the level of NF-κB, TNF-α, IL-1, and IL-6; Increase the expression of VEGF and CD31; Activate ERK signaling pathway; | [122] |
2 | hydrogel | Xanthan gum; hyaluronic acid sodium (HA); carboxymethyl chitosan(CMCS) | rabbit ear infected wounds | Increase the expression of α-SMA and CD31; Reduce the levels of pro-inflammatory factors | [138] |
3 | hydrogel | Poloxamer 407(P407); Hyaluronic Acid(HA); chitosan(CS) | back wound in mice | Increase the expression of HIF-1α, VEGF, CD31, and KRT; Inhibit the MAPK and NF-κB signal pathways; Increase the expression of LC3 | [123] |
4 | fibrous membrane | Poly(L-lactide) (PLA) | rabbit ear wounds | Decrease the level of COL-1 and VEGF; Inhibit inflammation | [133] |
5 | fibrous membrane | Poly(D,L-lactide-co-glycolide) (PLGA); Poly (dopamine) | rabbit ear wounds | Decrease the level of COL-1, CD31, and VEGF | [139] |
6 | fibrous membrane | Poly(D,L-lactide-co-glycolide) (PLGA); Chitosan (CS) | rabbit ear wounds | Decrease the expression of COL-1 and VEGF | [140] |
7 | fibrous membrane | Poly(γ-glutamic acid) (γ-PGA); Polyethylene oxide(PEO) | back wound in rats | Decrease the level of CD31 and VEGF | [141] |
8 | fibrous membrane | Poly(D,L-lactide-co-glycolide) (PLGA); Hyaluronic Acid(HA) | rabbit ear wounds | Decrease the expression of COL-1 | [132] |
9 | fibrous membrane | Poly(L-lactide) (PLLA) | rabbit ear wounds | Improve the collagen fiber density and micro vessels formation | [142] |
10 | fibrous membrane | polyurethane (PU); hydroxypropyl trimethyl ammonium chloride chitosan | third-degree burn wound in rats | Regulate the ratios of type I and III collagens; Increase the expression of α-SMA and CD31 | [143] |
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Yang, J.; Zhang, L.; Peng, X.; Zhang, S.; Sun, S.; Ding, Q.; Ding, C.; Liu, W. Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3. Molecules 2023, 28, 5066. https://doi.org/10.3390/molecules28135066
Yang J, Zhang L, Peng X, Zhang S, Sun S, Ding Q, Ding C, Liu W. Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3. Molecules. 2023; 28(13):5066. https://doi.org/10.3390/molecules28135066
Chicago/Turabian StyleYang, Jiali, Lifeng Zhang, **aojuan Peng, Shuai Zhang, Shuwen Sun, Qiteng Ding, Chuanbo Ding, and Wencong Liu. 2023. "Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3" Molecules 28, no. 13: 5066. https://doi.org/10.3390/molecules28135066