Potential New Inflammatory Markers in Bronchiectasis: A Literature Review

Bertuccio, Francesco Rocco; Baio, Nicola; Montini, Simone; Ferroni, Valentina; Chino, Vittorio; Pisanu, Lucrezia; Russo, Marianna; Giana, Ilaria; Cascina, Alessandro; Conio, Valentina; Grosso, Amelia; Gini, Erica; Albicini, Federica; Corsico, Angelo Guido; Stella, Giulia Maria

doi:10.3390/cimb46070398

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Potential New Inflammatory Markers in Bronchiectasis: A Literature Review

by

Francesco Rocco Bertuccio

^1,2,

Nicola Baio

^1,2,

Simone Montini

^1,2,

Valentina Ferroni

^1,2,

Vittorio Chino

³,

Lucrezia Pisanu

^1,2,

Marianna Russo

^1,2,

Ilaria Giana

^1,2,

Alessandro Cascina

^1,2

,

Valentina Conio

^1,2,

Amelia Grosso

²,

Erica Gini

²

,

Federica Albicini

²,

Angelo Guido Corsico

^1,2 and

Giulia Maria Stella

^1,2,*

¹

Unit of Respiratory Disease, Cardiothoracic and Vascular Department, IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy

²

Department of Internal Medicine and Pharmacology, University of Pavia, 27100 Pavia, Italy

³

Ospedale Pederzoli, Peschiera del Garda, 37121 Verona, Italy

^*

Author to whom correspondence should be addressed.

Curr. Issues Mol. Biol. 2024, 46(7), 6675-6689; https://doi.org/10.3390/cimb46070398 (registering DOI)

Submission received: 12 May 2024 / Revised: 22 June 2024 / Accepted: 24 June 2024 / Published: 29 June 2024

(This article belongs to the Special Issue Molecular and Real-World Evidence Research of Respiratory Diseases and Infections)

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Abstract

Specific molecular and inflammatory endotypes have been identified for chronic respiratory disorders, including asthma and COPD (chronic obstructive pulmonary disease). These endotypes correspond with clinical aspects of disease, enabling targeted medicines to address certain pathophysiologic pathways, often referred to as “precision medicine”. With respect to bronchiectasis, many comorbidities and underlying causes have been identified. Inflammatory endotypes have also been widely studied and reported. Additionally, several genes have been shown to affect disease progression. However, the lack of a clear classification has also hampered our understanding of the disease’s natural course. The aim of this review is, thus, to summarize the current knowledge on biomarkers and actionable targets of this complex pathologic condition and to point out unmet needs, which are required in the design of effective diagnostic and therapeutic trials.

Keywords: bronchiectasis; inflammatory molecular drivers; TSLP; mucins; endotype; personalised medicine

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MDPI and ACS Style

Bertuccio, F.R.; Baio, N.; Montini, S.; Ferroni, V.; Chino, V.; Pisanu, L.; Russo, M.; Giana, I.; Cascina, A.; Conio, V.; et al. Potential New Inflammatory Markers in Bronchiectasis: A Literature Review. Curr. Issues Mol. Biol. 2024, 46, 6675-6689. https://doi.org/10.3390/cimb46070398

AMA Style

Bertuccio FR, Baio N, Montini S, Ferroni V, Chino V, Pisanu L, Russo M, Giana I, Cascina A, Conio V, et al. Potential New Inflammatory Markers in Bronchiectasis: A Literature Review. Current Issues in Molecular Biology. 2024; 46(7):6675-6689. https://doi.org/10.3390/cimb46070398

Chicago/Turabian Style

Bertuccio, Francesco Rocco, Nicola Baio, Simone Montini, Valentina Ferroni, Vittorio Chino, Lucrezia Pisanu, Marianna Russo, Ilaria Giana, Alessandro Cascina, Valentina Conio, and et al. 2024. "Potential New Inflammatory Markers in Bronchiectasis: A Literature Review" Current Issues in Molecular Biology 46, no. 7: 6675-6689. https://doi.org/10.3390/cimb46070398

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Potential New Inflammatory Markers in Bronchiectasis: A Literature Review

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