Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates
Abstract
:1. Introduction
2. Materials and Methods
2.1. Informatics
2.2. Data and Code Availability
3. Results
3.1. Juxtaposed PrLDs, ZnFs and RRMs in the Most Deadly of Viruses
3.2. Metal Ion Binding Competition for ZnFs and RRMs Alters Protein Aggregate Stoichiometry
3.3. How Zn2+ and Zn2+-Chelation Both Cause Loss of Viral Capsid Integrity
3.4. Environmental Cu2+ as a Means to Control Viruses
3.5. Endogenous Cu2+ as a Means to Control Viruses
4. Discussion and Model Supporting Zn2+- and Cu2+-Mediated Control of Pan-Viruses
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Monette, A.; Mouland, A.J. Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates. Viruses 2020, 12, 1179. https://doi.org/10.3390/v12101179
Monette A, Mouland AJ. Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates. Viruses. 2020; 12(10):1179. https://doi.org/10.3390/v12101179
Chicago/Turabian StyleMonette, Anne, and Andrew J. Mouland. 2020. "Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates" Viruses 12, no. 10: 1179. https://doi.org/10.3390/v12101179