Curcumin for Treating Breast Cancer: A Review of Molecular Mechanisms, Combinations with Anticancer Drugs, and Nanosystems
Abstract
:1. Introduction
2. Bioavailability of Curcumin
3. Curcumin Biogenesis in the Regulation of Breast Cancer
3.1. CUR Inhibits p-Glycoprotein Activity and Reduces Drug Resistance in BC
3.2. Curcumin Induces Cell-Cycle Arrest in BC Cells
3.3. Curcumin Induces Apoptosis in BC Cells
4. Hybridization of Curcumin and Chemotherapeutic Drug Delivery in Nanosystems
4.1. Curcumin Encapsulated with Paclitaxel (PTX)
4.2. Curcumin Encapsulated with Tamoxifen (TAM)
4.3. Curcumin Encapsulated with Doxorubicin (DOX)
4.4. Curcumin Encapsulated with Methotrexate (MTX)
4.5. Curcumin Encapsulated with Other Chemotherapy Drugs
5. Delivery Platforms of Curcumin in Nanosystems
5.1. Polymers for the Delivery of Curcumin
5.2. Liposomal Formulations for the Delivery of Curcumin
5.3. Inorganic Nanomaterials for the Delivery of Curcumin
5.4. Polymeric Micelles for the Delivery of Curcumin
5.5. Newly Developed Platforms for the Delivery of Curcumin
6. Discussion
7. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Drug/Chemotherapeutic Nanosystem | Cell Line | Hydrated Size (nm) | Zeta-Potential (mV) | Entrapment Efficiency | Drug-Loading Capacity | Release Time | References |
---|---|---|---|---|---|---|---|
CUR-PTX-HA-HAD | MCF7 | 200–400 | −26.5 | 78.9 ± 5.5 | 23.8 | 12 | [62] |
CUR-TAM-niosomes | MCF7 | 159.45 | 98.37 | 20.68 ± 1.25 | 24 | [71] | |
CUR-MTX-PLGA | SK-BR-3 | 148.3 ± 4.07 | 3.41 ± 0.8 | 71.32 ± 7.8 | 22.1 ± 2.85 | 72 | [78] |
CUR-MTX-NCC | MCF-7 MDA-MB-231 | 336.7 | −33.1 | 22.44 | 48 | [77] | |
CUR-DTX-Lip | MCF7 | 208.53 ± 6.82 | −23.1 ± 2.1 | 98.32% ± 2.37% | 59.27% | 24 | [82] |
Nanosystem | Hydrated Size (nm) | Zeta-Potential (mV) | Entrapment Efficiency | Drug-Loading Capacity | Release Time | References |
---|---|---|---|---|---|---|
CUR-CS-ODA-Nanogel | 311 ± 20.29 | −13.25 ± 0.35 | 79.56 ± 5.56% | 6.55 ± 2.88% | 70 h | [93] |
CUR-ZIF8-NP-HA | 170.6 ± 11.2 | −18.10 ± 1.08 | 56.7% | 10.1 ± 1% | 10 h | [54] |
CUR-HA-PEG-PLGA-PEG | 153.4 ± 4.6 | −32.6 ± 2.5 | 6 h | [42] | ||
CUR-ZIF8-SF-PDA | 196 | −32 ± 30 | 44% | 8.2% | 24 h | [94] |
CUR-PTX-SLN | 238.5 ± 4.79 | −33.8 ± 1.26 | 94.2 ± 0.49% | 10.98 ± 0.31% | 24 h | [67] |
CUR-GANT61-PLGA-NPs | 347.4 ± 2.75 | −21.3 ± 0.23 | 98.3 ± 0.33% and 99.97 ± 0.09% | 25.6 ± 1.23% and 28.6 ± 2.05% | 24 h | [86] |
CUR-NIPAAm-MAA | 166 ± 6.0 | 89.6% | 24 h | [87] | ||
CUR-DOX-FA-NPs | 186.53 ± 2.78 | −18.87 | 97.64% | 20.27% | 24 h | [88] |
CUR-peptide-HSA-NPs | 246.5 ± 2.5 | −24.5 ± 1.5 | 77.8% | 5.52% | 12 h | [95] |
CUR-HA-NC | 161.85 ± 1.70 | −25.0 ± 0.8 | 80% | 48 h | [89] | |
Cu-ALG-CHITr-MNP | 122.4 ± 4.10 | 20–40 | 70% | 35% | 36 h | [96] |
CUR-Letrozole NiCoFe2O4-L-Silica-L-C-Niosome | 120.1 | 92.73%, 81.21% | 28.7% | 8 h | [97] | |
CUR-RGD-Lip | 97.4 ± 7.10 | 76.86 ± 7.52% | 28.96 ± 3% | 3 h | [98] | |
CUR-DTX-Lip | 208.53 ± 6.82 | −23.1 ± 2.1 | 98.32 ± 2.37% | 59.27% | 24 h | [82] |
CUR-PTX-NP | 125.1 ± 0.44 | −24.16 ± 0.22 | 54.12 ± 0.22% | 28.16% | 72 h | [61] |
CUR-Cis-NLips | 174.9 ± 18.4 | 99.81% | 23.86% | 24 | [99] |
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Zhu, J.; Li, Q.; Wu, Z.; Xu, Y.; Jiang, R. Curcumin for Treating Breast Cancer: A Review of Molecular Mechanisms, Combinations with Anticancer Drugs, and Nanosystems. Pharmaceutics 2024, 16, 79. https://doi.org/10.3390/pharmaceutics16010079
Zhu J, Li Q, Wu Z, Xu Y, Jiang R. Curcumin for Treating Breast Cancer: A Review of Molecular Mechanisms, Combinations with Anticancer Drugs, and Nanosystems. Pharmaceutics. 2024; 16(1):79. https://doi.org/10.3390/pharmaceutics16010079
Chicago/Turabian StyleZhu, **g, Qian Li, Zhong** Wu, Ying Xu, and Rilei Jiang. 2024. "Curcumin for Treating Breast Cancer: A Review of Molecular Mechanisms, Combinations with Anticancer Drugs, and Nanosystems" Pharmaceutics 16, no. 1: 79. https://doi.org/10.3390/pharmaceutics16010079