Epigenetic Contribution and Genomic Imprinting Dlk1-Dio3 miRNAs in Systemic Lupus Erythematosus
Abstract
:1. Introduction
2. DNA Methylation and SLE
3. Mechanism of DNA Hypomethylation in SLE
4. MiRNA and SLE
5. The Interplay of DNA Methylation and miRNA Regulation in SLE
6. Genomic Imprinting Dlk1-Dio3 Locus
7. Epigenetic Upregulation of Dlk1-Dio3 miRNAs in Murine Lupus
8. Potential Mechanism of the Dlk1-Dio3 miRNAs Involved in Autoimmune Disease Pathogenesis
9. Conclusions and Perspective
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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miRNA ID | Expression Change | Sample Source and Type | Method of Detection | Reference |
---|---|---|---|---|
miR-154, miR-127, miR-379, miR-382, miR-433, miR-300, miR-376b, miR-394, miR-299, miR-495, and miR-329 | Up | MRL-lpr splenocyte | Microarray | [77] |
miR-154, miR-127, miR-379, miR-382, miR-300, miR-433, and miR -411 | Up | MRL-lpr Splenocyte CD4+ T CD8+ B | RT-qPCR | [98] |
miR-127 and miR-379 | Up | NZBWF1 splenocyte | RT-qPCR | [77] |
miR-127 and miR-379 | Up | C3.MRL-Faslpr/J splenocyte | RT-qPCR | [122] |
miR-494 and miR-544 | Up | Human lupus PBMCs | Taqman low density array | [74] |
miR-134, miR-382, miR-409, miR-411, miR-493, miR-494, miR-544, and miR-654 | Up | Human lupus PBMCs | Small RNA-seq | [76] |
miR-494 | Up | Human lupus Naïve B | Taqman array | [129] |
miR-485-5p, miR-543, miR-410-3p, and miR-369-5p | Up | Human lupus Type IV nephritis plasma | Small RNA-seq | [123] |
miR-654 and miR-134 | Human lupus Type IV nephritis with cellular crescent Urinary exosome | Small RNA-seq | [126] | |
miR-134, miR-433, and miR-494 | Up | Human lupus nephritis renal biopsy | Microarray | [124] |
miR-485-3p | Up | Human discoid cutaneous lupus skin biopsy | Taqman array | [125] |
miR-379 | Down | Human lupus PBMCs | Taqman low density array | [74] |
miR-654 | Down | Human lupus PBMCs | RT-qPCR | [127] |
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Dai, R.; Wang, Z.; Ahmed, S.A. Epigenetic Contribution and Genomic Imprinting Dlk1-Dio3 miRNAs in Systemic Lupus Erythematosus. Genes 2021, 12, 680. https://doi.org/10.3390/genes12050680
Dai R, Wang Z, Ahmed SA. Epigenetic Contribution and Genomic Imprinting Dlk1-Dio3 miRNAs in Systemic Lupus Erythematosus. Genes. 2021; 12(5):680. https://doi.org/10.3390/genes12050680
Chicago/Turabian StyleDai, Rujuan, Zhuang Wang, and S. Ansar Ahmed. 2021. "Epigenetic Contribution and Genomic Imprinting Dlk1-Dio3 miRNAs in Systemic Lupus Erythematosus" Genes 12, no. 5: 680. https://doi.org/10.3390/genes12050680