Prognostic Value of Tpeak–Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Control Group (n = 27) | DMD, PVC < 1% Group 1 (n = 15) | DMD, PVC > 1% Group 2 (n = 10) | p-Value | |
---|---|---|---|---|
Age (years) | 13.2 ± 5 | 11.7 ± 4.5 | 14.6 ± 4.08 | 0.214 K |
BMI (kg/m2) | 25.7 ± 3.3 | 26.3 ± 6.6 | 26.9 ± 6.8 | 0.427 K |
Echocardiography | ||||
LVEF (%) | 67.6 ± 2.7 x,y | 59.9 ± 8.9 x,z | 50.5 ± 14.4 y,z | <0.001 A |
LVEDD (mm) | 41.0 ± 6.3 y | 43.7 ± 6.2 z | 50.4 ± 8.9 y,z | 0.005 A |
IVSd (mm) | 8.5 ± 1.2 x,y | 6.8 ± 0.8 x | 6.5 ± 0.6 y | <0.001 K |
PWd (mm) | 8.6 ± 1.1 x,y | 6.7 ± 0.7 x | 6.8 ± 0.5 y | <0.001 K |
Cardiac biomarkers | ||||
Pro-BNP (pg/mL) | 449 ± 18.3 x,y | 197.3 ± 235.1 x | 437.3 ± 574.8 y | 0.001 K |
Hs-Troponin (pg/mL) | 3.1 ± 1 x,y | 62.9 ± 51.2 x | 98.2 ± 32.1 y | <0.001 K |
Electrocardiography | ||||
PR interval (ms) | 140.9 ± 17.6 x,y | 117.5 ± 14.7 x | 124.2 ± 19.4 y | <0.001 K |
QRS duration (ms) | 95.3 ± 12.7 | 87.3 ± 5.7 | 94.4 ± 7.1 | 0.067 K |
QTc interval (ms) | 396.2 ± 14.9 x,y | 415.0 ± 19.9 x | 431.0 ± 20.4 y | <0.001 K |
Tp-e interval (ms) | 62.7 ± 2.8 y | 68.8 ± 7.8 z | 80.7 ± 18.9 y,z | <0.001 K |
24 h Holter monitoring | ||||
Max HR (bpm) | 159.0 ± 21.2 | 156.5 ± 12.7 | 149.0 ± 21.8 | 0.516 K |
Min HR (bpm) | 51.3 ± 12.8 | 56.9 ± 6.5 | 55.4 ± 6.9 | 0.222 A |
Average HR (bpm) | 84.3 ± 16.6 x,y | 91.9 ± 12.4 x | 92.9 ± 12.9 y | 0.016 K |
PVC per 24 h | 87.7 (0–1213) y | 218.2 (0–917) z | 5166.8 (1050–19,500) y,z | <0.001 K |
Couplets per 24 h | 0 ± 0 y | 0 ± 0 z | 5.4 ± 8.8 y,z | <0.001 K |
Triplets per 24 h | 0 ± 0 | 0 ± 0 | 1 ± 1 |
Variables | Tpeak–Tend | PVC | ||
---|---|---|---|---|
r | p-Value | r | p-Value | |
LVEF % | −0.312 | 0.024 * | −0.346 | 0.012 * |
LVEDD (mm) | 0.115 | 0.415 | 0.407 | 0.003 * |
Pro-BNP | 0.571 | <0.001 * | 0.353 | 0.038 * |
Hs-Troponin | 0.446 | 0.007 * | 0.623 | <0.001 * |
PR interval (ms) | −0.247 | 0.077 | –0.083 | 0.561 |
QRS duration (ms) | −0.224 | 0.110 | 0.106 | 0.453 |
QTc interval (ms) | 0.432 | 0.001 * | 0.459 | <0.001 * |
Tp-Te | — | — | 0.400 | 0.003 * |
PVC | 0.400 | 0.003 * | — | — |
Maximum HR | 0.002 | 0.990 | –0.102 | 0.471 |
Minimum HR | 0.266 | 0.057 | 0.170 | 0.229 |
Average HR | 0.267 | 0.056 | 0.245 | 0.080 |
Univariate Regression | Multivariate Regression | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
OR | %95 CI | p-Value | OR | %95 CI | p-Value | |||||
LVEF % | 0.879 | 0.812 | - | 0.953 | 0.002 * | 0.879 | 0.812 | - | 0.953 | 0.002 * |
Tp-e | 1.195 | 1.068 | - | 1.336 | 0.002 * | 1.181 | 1.047 | - | 1.332 | 0.007 * |
QTc | 1.088 | 1.027 | - | 1.153 | 0.004 * | |||||
LVEDD | 1.210 | 1.040 | - | 1.408 | 0.014 * | |||||
Pro-BNP | 1.002 | 1.000 | - | 1.005 | 0.074 | |||||
Hs-Troponin | 1.025 | 1.006 | - | 1.044 | 0.010 * | |||||
PR interval | 0.977 | 0.939 | - | 1.016 | 0.240 | |||||
QRS duration | 1.017 | 0.954 | - | 1.085 | 0.603 |
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Baskan, S.; Karaca Ozer, P.; Orta, H.; Ozbingol, D.; Yavuz, M.L.; Ayduk Govdeli, E.; Nisli, K.; Oztarhan, K. Prognostic Value of Tpeak–Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy. Diagnostics 2023, 13, 2381. https://doi.org/10.3390/diagnostics13142381
Baskan S, Karaca Ozer P, Orta H, Ozbingol D, Yavuz ML, Ayduk Govdeli E, Nisli K, Oztarhan K. Prognostic Value of Tpeak–Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy. Diagnostics. 2023; 13(14):2381. https://doi.org/10.3390/diagnostics13142381
Chicago/Turabian StyleBaskan, Serra, Pelin Karaca Ozer, Huseyin Orta, Doruk Ozbingol, Mustafa Lutfi Yavuz, Elif Ayduk Govdeli, Kemal Nisli, and Kazim Oztarhan. 2023. "Prognostic Value of Tpeak–Tend Interval in Early Diagnosis of Duchenne Muscular Dystrophy Cardiomyopathy" Diagnostics 13, no. 14: 2381. https://doi.org/10.3390/diagnostics13142381