Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. The Participants
2.2. Evaluation of Anthropometric Parameters
2.3. Laboratory Parameters
2.4. Assessment of Arterial Stiffness
2.5. Statistical Analysis
3. Results
3.1. Patients’ Characteristics
3.2. Determinants of Brachial-Ankle PWV
3.3. Analysis of the Subgroups
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Parameter | Group (n = 68) |
---|---|
Age (years) | 69 (62.5, 76) |
Male, n (%) | 36 (52.9) |
Diabetes mellitus 1, n (%) | 28 (41.2) |
Hypertension, n (%) | 60 (89.6) |
SBP (mmHg) | 144 (126.5, 162) |
DBP (mmHg) | 87.07 ± 12.42 |
PP (mmHg) | 58 (45.5, 72.5) |
eGFR (mL/min/1.73 m2) | 27 (15, 42) |
Body mass index (kg/m2) | 28.6 (26.4, 30.35) |
LTM (kg) | 38.25 ± 12.16 |
ATM (kg) | 41.74 ± 13.77 |
Total cholesterol (mg/dL) | 177.49 ± 37.45 |
LDL-cholesterol (mg/dL) | 98.73 ± 28.61 |
HDL-cholesterol (mg/dL) | 43.86 ± 12.94 |
Triglycerides (mg/dL) | 125 (91.5, 166) |
Fasting glucose (mg/dL) | 103 (92, 131) |
Calcium (mg/dL) | 9.2 (8.64, 9.69) |
Phosphorus (mg/dL) | 3.66 (3.14, 4.56) |
iPTH (pg/mL) | 108.85 (84.85, 227.35) |
Alkaline phosphatase (UI/L) | 80 (72, 96.5) |
Hemoglobin (g/dL) | 12.46 ± 2.22 |
Serum albumin (g/L) | 3.89 ± 0.49 |
hs-C reactive protein (mg/dL) | 0.47 (0.23, 1.19) |
White blood cells (no./mm3) | 7625 (6340, 9050) |
TNF-α (pg/mL) | 4.4 (2.94, 6.8) |
IL-6 (pg/mL) | 2.44 (1.7, 3.55) |
IL-1β (pg/mL) | 7.06 (6.45, 12.99) |
Prolactin (ng/mL) | 4.83 (3.1, 7.76) |
Triiodothyronine (ng/mL) | 1.2 (0.9, 1.3) |
Brachial-ankle PWV (m/s) | 10.55 ± 2.17 |
ACEI/ARB, n (%) | 29 (42.6) |
Parameters | r—Coefficient of Correlation | p |
---|---|---|
Age (years) | 0.92 | <0.001 |
SBP (mmHg) | 0.56 | <0.001 |
PP (mmHg) | 0.57 | <0.001 |
Lean tissue mass (kg) | −0.45 | 0.001 |
Prolactin (ng/mL) | −0.27 | 0.026 |
Triiodothyronine (ng/mL) | −0.25 | 0.040 |
Total Cholesterol(mg/dL) | −0.26 | 0.042 |
Triglycerides (mg/dL) | −0.34 | 0.023 |
Parameter | Non-Diabetes Subgroup (n = 38) | Diabetes Subgroup (n = 28) | p |
---|---|---|---|
Age (years) | 68.5 (61, 76) | 68 (62.5, 76) | 0.689 |
Male, n (%) | 17 (45.9) | 13 (46.4) | 0.969 |
Hypertension, n (%) | 34 (89.5) | 24 (88.9) | 0.940 |
SBP (mmHg) | 138 (121, 156) | 150.5 (138.5, 172) | 0.010 |
DBP (mmHg) | 82 (76, 98) | 89 (80, 97.5) | 0.508 |
PP (mmHg) | 49.5 (41, 68) | 63 (52, 74) | 0.009 |
eGFR (mL/min/1.73 m2) | 26 (19, 38) | 27.85 (12.5, 47) | 0.910 |
BMI (kg/m2) | 28.45 (25.5, 29.9) | 29.5 (27.1, 31.55) | 0.109 |
LTM (kg) | 38.35 ± 12 | 38.13 ± 12.63 | 0.948 |
ATM (kg) | 38.27 ± 12.19 | 46.22 ± 14.62 | 0.032 |
Total cholesterol (mg/dL) | 185.97 ± 36.06 | 168.62 ± 36.58 | 0.072 |
Triglycerides (mg/dL) | 130 (94, 159.5) | 124 (85.5, 175.5) | 0.961 |
Calcium (mg/dL) | 9.34 (8.67, 9.76) | 9.17 (8.78, 9.47) | 0.410 |
Phosphorus (mg/dL) | 3.63 (3.13, 4.41) | 3.7 (3.3, 5.22) | 0.425 |
TNF-α (pg/mL) | 4.6 (3.11, 6.03) | 4.02 (2.69, 8.3) | 0.678 |
IL-6 (pg/mL) | 2.44 (1.7, 3.27) | 2.2 (1.6, 4.36) | 0.830 |
IL-1β (pg/mL) | 6.86 (6.38, 9.96) | 9.54 (6.79, 19.35) | 0.015 |
Prolactin (ng/mL) | 4.98 (3.07, 8.16) | 4.66 (3.91, 7.24) | 0.912 |
Triiodothyronine (ng/mL) | 1.2 (0.9, 1.3) | 1.1 (0.9, 1.35) | 0.568 |
Brachial-ankle PWV (m/s) | 10.14 ± 2.42 | 10.94 ± 1.58 | 0.135 |
Parameters | r—Coefficient of Correlation | p |
---|---|---|
Age (years) | 0.89 | <0.001 |
Phosphorus (mg/dL) | −0.51 | 0.014 |
eGFR (mL/min/1.73 m2) | 0.11 | 0.593 |
TNF-α (pg/mL) | 0.47 | 0.012 |
IL-6 (pg/mL) | 0.40 | 0.034 |
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Rusu, C.C.; Kacso, I.; Moldovan, D.; Potra, A.; Tirinescu, D.; Ticala, M.; Rotar, A.M.; Orasan, R.; Budurea, C.; Barar, A.; et al. Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients. Diagnostics 2023, 13, 2462. https://doi.org/10.3390/diagnostics13142462
Rusu CC, Kacso I, Moldovan D, Potra A, Tirinescu D, Ticala M, Rotar AM, Orasan R, Budurea C, Barar A, et al. Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients. Diagnostics. 2023; 13(14):2462. https://doi.org/10.3390/diagnostics13142462
Chicago/Turabian StyleRusu, Crina Claudia, Ina Kacso, Diana Moldovan, Alina Potra, Dacian Tirinescu, Maria Ticala, Ancuta M. Rotar, Remus Orasan, Cristian Budurea, Andrada Barar, and et al. 2023. "Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients" Diagnostics 13, no. 14: 2462. https://doi.org/10.3390/diagnostics13142462