Presence of KIR2DL2/S2, KIR2DL5, and KIR3DL1 Molecules in Liver Transplant Recipients with Alcoholic Cirrhosis Could Be Implicated in Death by Graft Failure
Abstract
:1. Introduction
2. Material and Methods
2.1. Enrollment of Patients
2.2. Alcoholic Cirrhosis Diagnostic Criteria
2.3. Diagnosis of Immune Suppression and Rejection
2.4. Causes of Mortality in Alcoholic Cirrhosis Patients
2.5. KIR Genoty**
2.6. Statistical Analyses
3. Results
3.1. Clinical and Sociodemographic Characteristics
3.2. Frequency of KIR Genes in AC Patients with Different Causes of Death
3.3. Analysis of the Frequency of the Presence of KIR Genes in Causes of Death in Patients with and without Ascites
3.4. Analysis of the Frequency of KIR Genes in the Causes of Death of AC Patients with and without Encephalopathy
3.5. Influence of iKIR on Time Elapsed between the Transplantation and the Cause of Death
3.6. Influence of aKIR on Time Elapsed between Transplantation and Cause of Death
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Total AC Patients N = 164, n (%) | |
---|---|
Recipient | |
Mean age * (mean years ± SD) | 54.3 ± 6.9 |
Sex (male/female) | 150 (91.4)/14 (8.6) |
Ascites+ Mean age | 118 (71.9) 54.2 ± 1.3 |
Encephalopathy+ Mean age | 39 (23.7) 56.7 ± 2.0 |
Causes of death | |
Sepsis | 39 (23.7) |
Graft failure | 32 (19.5) |
Multiorgan failure | 29 (17.7) |
Others ** | 64 (39.1) |
Causes of Death | |||
---|---|---|---|
Multiorgan Failure (MF) (N = 29) | Sepsis (S) (N = 39) | Graft Failure (GF) (N = 32) | |
KIR Genes | n (%) | n (%) | n (%) |
iKIRs | |||
KIR2DL1+/S1− | 19 (65.5) | 23 (58.9) | 22 (68.7) |
KIR2DL2+ | 22 (75.8) a | 21 (53.8) | 14 (43.7) |
KIR2DL3+ | 26 (89.6) | 36 (92.3) | 30 (93.7) |
KIR3DL1+ | 24 (82.7) | 31 (79.4) | 30 (93.7) |
aKIRs | |||
KIR2DS1+ | 11 (37.9) | 13 (33.3) | 10 (31.2) |
KIR2DS2+ | 22 (75.8) b | 20 (51.2) c | 14 (43.7) |
KIR2DS3+ | 9 (31.0) | 7 (17.9) | 10 (31.2) |
KIR2DS4+ | 24 (82.7) | 31 (79.4) | 30 (93.7) |
KIR2DS5+ | 11 (37.9) | 12 (30.7) | 10 (31.2) |
Wald | p | OR | 95% CI | ||
---|---|---|---|---|---|
Lower | Upper | ||||
Sepsis | |||||
KIR2DL2 | 0.785 | 0.376 | 0.432 | 0.067 | 2.768 |
KIR2DL5 | 0.000 | 0.996 | 1.007 | 0.064 | 15.856 |
KIR3DL1 | 4.056 | 0.044 | 0.025 | 0.001 | 0.906 |
KIR2DS1 | 0.989 | 0.320 | 0.176 | 0.006 | 5.413 |
Ascites | 1.371 | 0.242 | 3.432 | 0.436 | 27.042 |
Encephalopathy | 0.148 | 0.700 | 0.698 | 0.112 | 4.364 |
Graft failure | |||||
KIR2DL2 | 1.580 | 0.209 | 0.316 | 0.052 | 1.907 |
KIR2DL5 | 0.141 | 0.707 | 1.636 | 0.126 | 21.272 |
KIR3DL1 | 0.117 | 0.732 | 1.812 | 0.060 | 54.295 |
KIR2DS1 | 0.064 | 0.801 | 1.468 | 0.075 | 28.890 |
Ascites | 2.517 | 0.113 | 0.117 | 0.008 | 1.658 |
Encephalopathy | 1.068 | 0.301 | 2.825 | 0.394 | 20.245 |
Multiorgan failure | |||||
KIR2DL2 | 3.148 | 0.076 | 8.911 | 0.795 | 99.821 |
KIR2DL5 | 2.652 | 0.103 | 0.122 | 0.010 | 1.535 |
KIR3DL1 | 1.008 | 0.315 | 0.144 | 0.003 | 6.333 |
Ascites | 0.190 | 0.663 | 1.621 | 0.184 | 14.241 |
Encephalopathy | 1.359 | 0.224 | 0.270 | 0.030 | 2.443 |
Wald | p | OR | 95% CI | ||
---|---|---|---|---|---|
Lower | Upper | ||||
Age | 0.719 | 0.396 | 2.033 | 0.394 | 10.489 |
KIR3DL1 | 3.443 | 0.034 | 3.979 | 0.925 | 17.110 |
KIR2DS1 | 3.520 | 0.041 | 2.736 | 0.956 | 7.831 |
KIR2DS3 | 0.088 | 0.026 | 1.140 | 0.479 | 2.715 |
KIR2DS4 | 0.064 | 0.801 | 1.468 | 0.075 | 18.890 |
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Morales, R.; Bolarín, J.M.; Muro, M.; Legaz, I. Presence of KIR2DL2/S2, KIR2DL5, and KIR3DL1 Molecules in Liver Transplant Recipients with Alcoholic Cirrhosis Could Be Implicated in Death by Graft Failure. Diagnostics 2023, 13, 1217. https://doi.org/10.3390/diagnostics13071217
Morales R, Bolarín JM, Muro M, Legaz I. Presence of KIR2DL2/S2, KIR2DL5, and KIR3DL1 Molecules in Liver Transplant Recipients with Alcoholic Cirrhosis Could Be Implicated in Death by Graft Failure. Diagnostics. 2023; 13(7):1217. https://doi.org/10.3390/diagnostics13071217
Chicago/Turabian StyleMorales, Raquel, José Miguel Bolarín, Manuel Muro, and Isabel Legaz. 2023. "Presence of KIR2DL2/S2, KIR2DL5, and KIR3DL1 Molecules in Liver Transplant Recipients with Alcoholic Cirrhosis Could Be Implicated in Death by Graft Failure" Diagnostics 13, no. 7: 1217. https://doi.org/10.3390/diagnostics13071217