Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors
Abstract
:1. Introduction
2. Materials and Methods
2.1. Sample
2.2. Inclusion and Exclusion Criteria
2.3. Antidepressant Treatment
2.4. Clinical and Biochemical Evaluations
2.5. Statistical Analysis
3. Results
3.1. No Differences in Relapse Were Observed in Depressive Patients, Regardless of Liver Enzyme Levels
3.2. SNRI Treatment Should Be Avoided in Patients with Any Type of Alcohol Consumption
3.3. Relapsing Male Patients Exhibid Higher GGT Levels Compared to Those without Any Relapse Episode
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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AST Blood Levels | ALT Blood Levels | AST/ALT Ratio | GGT Blood Levels | ||
---|---|---|---|---|---|
Normal Values | 1–40 U/L | 1–41 U/L | <1.1 | 1–38 U/L | |
Descriptive statistics of the studied population | Mean | 29.24 | 28.75 | 1.07 | 40.93 |
Std. Deviation | 20.1 | 16.4 | 0.4 | 32.1 | |
Minimum | 9.8 | 5.5 | 0.4 | 10.4 | |
Maximum | 116.5 | 102.7 | 3.2 | 180.2 | |
Range | 106.7 | 97.2 | 2.8 | 169.8 | |
Skewness | 2.2 | 1.4 | 1.6 | 2.2 | |
Kurtosis | 4.9 | 2.5 | 3.7 | 5.5 | |
Test for normal distribution D’Agostino & Pearson test | K2 | 110.9 | 64.6 | 79.4 | 114.5 |
p value | <0.0001 | <0.0001 | <0.0001 | <0.0001 | |
Passed normality test (alpha = 0.05)? | No | No | No | No |
Total | SSRI | SNRI | TCA | SARI | NaSSA | ||
---|---|---|---|---|---|---|---|
Included patients | No. of patients | 221 | 72 | 40 | 34 | 61 | 14 |
Mean age (years) | 53.99 ± 8.94 | 53.19 ± 8.15 | 54.58 ± 8.93 | 51.50 ± 9.37 | 54.97 ± 9.72 | 58.14 ± 6.87 | |
Gender Distribution (M:F) | 76:145 | 13:59 | 18:22 | 18:16 | 23:38 | 4:10 | |
No relapse | No. of patients | 143 | 44 | 23 | 21 | 45 | 10 |
Mean age (years) | 53.52 ± 9.68 | 54.32 ± 7.60 | 54.17 ± 10.50 | 49.33 ± 10.56 | 53.87 ± 10.75 | 58.10 ± 7.34 | |
Gender Distribution (M:F) | 49:94 | 10:34 | 9:14 | 10:11 | 18:27 | 2:8 | |
Relapse episodes | No. of patients | 78 | 28 | 17 | 13 | 16 | 4 |
Mean age (years) | 54.83 ± 7.36 | 51.46 ± 8.79 | 56.35 ± 6.04 | 55.00 ± 5.87 | 58.06 ± 5.05 | 58.50 ± 6.55 | |
Gender Distribution (M:F) | 27:51 | 3:25 | 9:8 | 8:5 | 5:11 | 2:2 |
SSRI | SNRI | TCA | NaSSA | SARI | ||||||
---|---|---|---|---|---|---|---|---|---|---|
OR | p Value | OR | p Value | OR | p Value | OR | p Value | OR | p Value | |
Elevated AST | 0.936 | 0.932 | 9.167 | 0.028 | 1.016 | 0.983 | INC. | INC. | 1.253 | 0.767 |
Elevated ALT | 1.442 | 0.553 | 2.778 | 0.201 | 0.593 | 0.481 | INC. | INC. | 0.433 | 0.445 |
Elevated GGT | 1.015 | 0.977 | 5.344 | 0.018 | 3.000 | 0.134 | INC. | INC. | 0.622 | 0.440 |
Elevated AST/ALT | 0.889 | 0.831 | 1.545 | 0.530 | 0.467 | 0.297 | 0.778 | 0.852 | 0.750 | 0.630 |
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Mușat, M.I.; Militaru, F.; Gheorman, V.; Udriștoiu, I.; Mitran, S.I.; Cătălin, B. Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors. Diagnostics 2024, 14, 1140. https://doi.org/10.3390/diagnostics14111140
Mușat MI, Militaru F, Gheorman V, Udriștoiu I, Mitran SI, Cătălin B. Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors. Diagnostics. 2024; 14(11):1140. https://doi.org/10.3390/diagnostics14111140
Chicago/Turabian StyleMușat, Mădălina Iuliana, Felicia Militaru, Victor Gheorman, Ion Udriștoiu, Smaranda Ioana Mitran, and Bogdan Cătălin. 2024. "Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors" Diagnostics 14, no. 11: 1140. https://doi.org/10.3390/diagnostics14111140