Molecular and Cellular Mechanisms Affected in ALS
Abstract
:1. Introduction
2. Oxidative Stress
3. Mitochondrial Dysfunction
4. Axonal Transport
5. Glutamate Excitotoxicity
6. Endosomal Pathway and Vesicle Secretion
7. Impaired Protein Homeostasis
7.1. Proteasome and Autophagic Degradation Pathways
7.2. Endoplasmic Reticulum Stress
8. Aberrant RNA Metabolism
8.1. RNA Splicing and Translation
8.2. RNA Foci
8.3. Epigenetic Modulation
8.4. Stress Granules and Nucleocytoplasmic Transport
9. Concluding Remarks
Author Contributions
Funding
Conflicts of Interest
References
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Le Gall, L.; Anakor, E.; Connolly, O.; Vijayakumar, U.G.; Duddy, W.J.; Duguez, S. Molecular and Cellular Mechanisms Affected in ALS. J. Pers. Med. 2020, 10, 101. https://doi.org/10.3390/jpm10030101
Le Gall L, Anakor E, Connolly O, Vijayakumar UG, Duddy WJ, Duguez S. Molecular and Cellular Mechanisms Affected in ALS. Journal of Personalized Medicine. 2020; 10(3):101. https://doi.org/10.3390/jpm10030101
Chicago/Turabian StyleLe Gall, Laura, Ekene Anakor, Owen Connolly, Udaya Geetha Vijayakumar, William J. Duddy, and Stephanie Duguez. 2020. "Molecular and Cellular Mechanisms Affected in ALS" Journal of Personalized Medicine 10, no. 3: 101. https://doi.org/10.3390/jpm10030101