Orchestrating Asymmetric Expression: Mechanisms behind **st Regulation
Abstract
:1. Introduction
1.1. Kicking off X Chromosome Inactivation: The Stochastic Model
1.2. The X Inactivation Center and the Tsix/** histone demethylases, KDM5C/JARID1C and KDM6A/UTX, implicated in sexual differentiation (see review [52]) with opposing roles in enhancing ** gene, Kdm6a, might be involved in ** XCI [90,91]. RNA FISH experiments indicated that when expressed from the ** XCI, with its nascent RNA detected adjacent to ** mechanisms. Given how essential XCI is for cell survival during female development, the presence of several redundant, “fool proof” mechanisms seems evolutionarily sensible.
Supplementary Materials
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Luchsinger-Morcelle, S.J.; Gribnau, J.; Mira-Bontenbal, H. Orchestrating Asymmetric Expression: Mechanisms behind **st Regulation. Epigenomes 2024, 8, 6. https://doi.org/10.3390/epigenomes8010006
Luchsinger-Morcelle SJ, Gribnau J, Mira-Bontenbal H. Orchestrating Asymmetric Expression: Mechanisms behind **st Regulation. Epigenomes. 2024; 8(1):6. https://doi.org/10.3390/epigenomes8010006
Chicago/Turabian StyleLuchsinger-Morcelle, Samuel Jesus, Joost Gribnau, and Hegias Mira-Bontenbal. 2024. "Orchestrating Asymmetric Expression: Mechanisms behind **st Regulation" Epigenomes 8, no. 1: 6. https://doi.org/10.3390/epigenomes8010006