Abstract
Influenza viruses are the leading cause of upper respiratory tract infections, leading to several global pandemics and threats to public health. Due to the continuous mutation of influenza A viruses, there is a constant need for the development of novel antiviral therapeutics. Recently, natural antimicrobial peptides have provided an opportunity for the discovery of anti-influenza molecules. Here, we designed several peptides based on pheasant cathelicidin and tested their antiviral activities and mechanisms against the H1N1 virus. Of note, the designed peptides Pc-4 and Pc-5 were found to inhibit replication of the H1N1 virus with an IC50 = 8.14 ± 3.94 µM and 2.47 ± 1.95 µM, respectively. In addition, the cyclic peptide Pc-5 was found to induce type I interferons and the expression of interferon-induced genes. An animal study showed that the cyclic peptide Pc-5 effectively inhibited H1N1 virus infection in a mouse model. Taken together, our work reveals a strategy for designing cyclic peptides and provides novel molecules with therapeutic potential against influenza A virus infection.
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MDPI and ACS Style
Pei, Y.; Chen, Z.; Zhao, R.; An, Y.; Yisihaer, H.; Wang, C.; Bai, Y.; Liang, L.; **, L.; Hu, Y.
A Cyclic Peptide Based on Pheasant Cathelicidin Inhibits Influenza A H1N1 Virus Infection. Antibiotics 2024, 13, 606.
https://doi.org/10.3390/antibiotics13070606
AMA Style
Pei Y, Chen Z, Zhao R, An Y, Yisihaer H, Wang C, Bai Y, Liang L, ** L, Hu Y.
A Cyclic Peptide Based on Pheasant Cathelicidin Inhibits Influenza A H1N1 Virus Infection. Antibiotics. 2024; 13(7):606.
https://doi.org/10.3390/antibiotics13070606
Chicago/Turabian Style
Pei, Ya**, Zhihua Chen, Ruihan Zhao, Yanxing An, Haiche Yisihaer, Chaojie Wang, Yaning Bai, Libin Liang, Lin **, and Yongting Hu.
2024. "A Cyclic Peptide Based on Pheasant Cathelicidin Inhibits Influenza A H1N1 Virus Infection" Antibiotics 13, no. 7: 606.
https://doi.org/10.3390/antibiotics13070606
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