Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement
Abstract
:1. Introduction
1.1. Characteristics and Prevalence of ADHD
1.2. Factors Associated with ADHD
1.3. Aim and Scope
2. Materials and Methods
2.1. Population Sample and Diagnostic Assessment
2.2. Genoty**
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Age (Mean ± SD) | 10.8 ± 0.84 |
Sex (n, %) | |
Female | 6 (7.5%) |
Male | 74 (92.5%) |
MAOA rs6323F | 5′-TAATTAATGCGATCCCTCCG-3′ |
MAOArs6323 R | 5′-TGAGGAAATTGACAGACCAAGA-3′ |
MAOA rs1137070F | 5′-GGCAACGTTTTTGGCATCTGGTC-3′ |
MAOArs1137070 R | 5′-ACTCATGCTGACAAGGAGGAACA-3′ |
ADHD | Controls | p | OR | |||
---|---|---|---|---|---|---|
MAOA SNP rs6323 (G891T) | ||||||
Genotypes | n = 80 | % | n = 80 | % | ||
TT | 56 | 0.70 | 51 | 0.64 | ns § | - |
GT | 4 | 0.05 | 21 | 0.26 | 0.0008 | 0.1479 |
GG | 20 | 0.25 | 8 | 0.10 | 0.02 | 3.0 |
Alleles | 2n = 160 | % | 2n = 160 | % | ||
T | 116 | 0.73 | 123 | 0.77 | ns § | - |
G | 44 | 0.27 | 37 | 0.23 | ns § | - |
MAOA SNP rs1137070 (T1410C) | ||||||
Genotypes | n = 80 | % | n = 81 * | % | ||
CC | 56 | 0.70 | 51 | 0.63 | ns § | - |
CT | 5 | 0.06 | 21 | 0.26 | 0.0006 | 0.19 |
TT | 19 | 0.24 | 9 | 0.11 | 0.0344 | 2.49 |
Alleles | 2n = 160 | % | 2n = 162 | % | ||
C | 117 | 0.73 | 123 | 0.76 | ns § | - |
T | 43 | 0.27 | 39 | 0.24 | ns § | - |
Aggress. ADHD | Non-Aggress. ADHD | Controls | ||||
---|---|---|---|---|---|---|
MAOA SNP rs6323 (G891T) | ||||||
Genotypes | n = 32 | % | n = 48 | % | n = 80 | % |
TT | 22 | 0.70 | 34 | 0.71 | 51 | 0.64 |
GT | 3 | 0.10 | 1 | 0.02 | 21 | 0.26 |
GG | 7 | 0.20 | 13 | 0.27 | 8 | 0.10 |
Alleles | 2n = 64 | % | 2n = 96 | % | 2n = 160 | % |
T | 47 | 0.74 | 69 | 0.77 | 123 | 0.77 |
G | 17 | 0.26 | 27 | 0.23 | 37 | 0.23 |
MAOA SNP rs1137070 (T1410C) | ||||||
Genotypes | n = 32 | % | n = 48 | % | n = 81 * | % |
CC | 22 | 0.70 | 34 | 0.71 | 51 | 0.63 |
CT | 3 | 0.10 | 3 | 0.06 | 21 | 0.26 |
TT | 7 | 0.20 | 11 | 0.23 | 9 | 0.11 |
Alleles | 2n = 64 | % | 2n = 96 | % | 2n = 162 | % |
C | 47 | 0.73 | 71 | 0.74 | 123 | 0.76 |
T | 17 | 0.27 | 25 | 0.26 | 39 | 0.24 |
Aggressive ADHD | Non-Aggressive ADHD | |||
---|---|---|---|---|
5HTT SNP | ||||
rs4795541(S)/(L) Polymorphism | ||||
Genotypes | n = 32 | % | n = 48 | % |
LL | 11 | 0.70 | 11 | 0.23 |
LS | 16 | 0.10 | 28 | 0.58 |
SS | 5 | 0.20 | 9 | 0.18 |
Alleles | 2n = 64 | % | 2n = 96 | % |
L | 38 | 0.60 | 50 | 0.52 |
S | 26 | 0.40 | 46 | 0.48 |
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Neri, L.; Marziani, B.; Sebastiani, P.; Del Beato, T.; Colanardi, A.; Legge, M.P.; Aureli, A. Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement. Diseases 2024, 12, 70. https://doi.org/10.3390/diseases12040070
Neri L, Marziani B, Sebastiani P, Del Beato T, Colanardi A, Legge MP, Aureli A. Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement. Diseases. 2024; 12(4):70. https://doi.org/10.3390/diseases12040070
Chicago/Turabian StyleNeri, Ludovico, Beatrice Marziani, Pierluigi Sebastiani, Tiziana Del Beato, Alessia Colanardi, Maria Pia Legge, and Anna Aureli. 2024. "Aggressiveness in Italian Children with ADHD: MAOA Gene Polymorphism Involvement" Diseases 12, no. 4: 70. https://doi.org/10.3390/diseases12040070