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Sci. Pharm.
Volume 70
Issue 2
10.3797/scipharm.aut-02-18
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

The Beneficial Interaction Between Enalapril and Danazol in Normal Rat

by
Mansour M.
*,
El-Hadiyah T.
,
Ginawi O.
,
Mostafa A.
,
Al-Majed A.
and
Al-Shabanah O.
Department of Pharmacology, College of Pharmacy, King Saud University, P.0 Box 2457, kyadh 1 145 1, Saudi Arabia
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(2), 165-175; https://doi.org/10.3797/scipharm.aut-02-18
Submission received: 9 May 2001 / Revised: 20 February 2002 / Accepted: 20 February 2002 / Published: 20 May 2002
Versions Notes

Abstract

Danazol, a weekly androgenic, heterocyclic compound with anabolic properties, is used primarily in the treatment of endometriosis and other gynecological complaints. Effects of co-administration of enalapril, an angiotensin converting enzyme inhibitor (ACE inhibitor) with danazol on some biochemical parameters in rats were studied. Treatment of rats with danazol (200mglkg i.p) for 15 days induced a significant elevation of serum aspartate transaminase activity (AST, EC: 2.6.1.1), triglycerides (TG) and induced a significant decrease in serum cholesterol. However, enalapril treatment (20mglkg i.p) for 15 days caused a significant elevation of serum alanine transaminase activity (ALT, EC: 2.6.1.2). Co-administration of danazol and enalapril significantly lowered the elevated levels of serum transaminases enzyme activities and serum TG. It could be concluded that long term treatment with enalapril might be beneficial in patients danazol in clinical situations through protection against undesirable side effects.

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MDPI and ACS Style

M., M.; T., E.-H.; O., G.; A., M.; A., A.-M.; O., A.-S. The Beneficial Interaction Between Enalapril and Danazol in Normal Rat. Sci. Pharm. 2002, 70, 165-175. https://doi.org/10.3797/scipharm.aut-02-18

AMA Style

M. M, T. E-H, O. G, A. M, A. A-M, O. A-S. The Beneficial Interaction Between Enalapril and Danazol in Normal Rat. Scientia Pharmaceutica. 2002; 70(2):165-175. https://doi.org/10.3797/scipharm.aut-02-18

Chicago/Turabian Style

M., Mansour, El-Hadiyah T., Ginawi O., Mostafa A., Al-Majed A., and Al-Shabanah O. 2002. "The Beneficial Interaction Between Enalapril and Danazol in Normal Rat" Scientia Pharmaceutica 70, no. 2: 165-175. https://doi.org/10.3797/scipharm.aut-02-18

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