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Sci. Pharm.
Volume 70
Issue 3
10.3797/scipharm.aut-02-27
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Article

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW FLAVONOID DERIVATIVES FROM 4,6-DIACETYL RESORCINOL

by
Khan M.S.Y.
*,
Sharma S.
and
Husain A.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jarnia Harndard, New Delhi- 110062, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2002, 70(3), 287-294; https://doi.org/10.3797/scipharm.aut-02-27
Submission received: 16 January 2002 / Revised: 23 March 2002 / Accepted: 23 March 2002 / Published: 10 September 2002
Versions Notes

Abstract

In order to check the antibacterial potential of bischalcones derived from 4,6-diacetyl resorcinol, a number of chalcone derivatives were synthesized by condensation with appropriate aromatic aldehydes. Out of these compounds 3b-i, 4a and 4b showed a good antibacterial activity. Methylation of the two chelated hydroxyls reduced the activity. However, oxidative cyclization of 3a and 3b resulted in compounds 4a and 4b which were found to be considerably active. The alternative method of synthesis of 4a and 4b via Baker-Venkatararnan rearrangement did not succeed.
Keywords: Flavones, bischalcones, resorcinol, antibacterial Flavones, bischalcones, resorcinol, antibacterial

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MDPI and ACS Style

M.S.Y., K.; S., S.; A., H. SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW FLAVONOID DERIVATIVES FROM 4,6-DIACETYL RESORCINOL. Sci. Pharm. 2002, 70, 287-294. https://doi.org/10.3797/scipharm.aut-02-27

AMA Style

M.S.Y. K, S. S, A. H. SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW FLAVONOID DERIVATIVES FROM 4,6-DIACETYL RESORCINOL. Scientia Pharmaceutica. 2002; 70(3):287-294. https://doi.org/10.3797/scipharm.aut-02-27

Chicago/Turabian Style

M.S.Y., Khan, Sharma S., and Husain A. 2002. "SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW FLAVONOID DERIVATIVES FROM 4,6-DIACETYL RESORCINOL" Scientia Pharmaceutica 70, no. 3: 287-294. https://doi.org/10.3797/scipharm.aut-02-27

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