Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions?
Abstract
:1. Red Blood Cells Transfusion
2. Red Blood Cells Aging (In Vitro and In Vivo)
2.1. In Vivo Aging
2.2. In Vitro Aging (Cold-Storage)
3. Sugar as a Potential Factor of RBC Lesion
4. Limitation
5. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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T2 Diabetes | RBC Storage | |
---|---|---|
Elevated Hemolysis/Free Heme | [67] | [68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85] |
Elevated Membrane Phosphatidylserine exposure | [86,87] | [88,89,90,91,92] |
Elevated HbA1C | [93,94,95,96,97] | [73,98,99,100,101,102,103] |
Elevated Intra-RBC ROS concentration | [100,102] | [71,104,105] |
Decreased levels/activity of RBC GSH and other antioxidant systems | [102,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134] | [69,104,135,136,137,138] |
Elevated Intracellular AGE | [58,102,139,140,141,142,143,144,145,146,147] | [148,149] |
Abnormalities in Nitric oxide signaling and decreased RBC nitric oxide synthase (RBC-NOS) activity | [150] | [84,151] |
Decreased 2,3 DPG level | [152,153,154,155] | [33,70,73,88,156,157,158,159,160,161,162,163] |
Abnormalities in Na/K levels and decreased Na+/K+-ATPase activity | [128,141,164,165,166,167,168,169,170,171,172,173,174,175,176] | [70,72,177,178,179,180,181,182,183,184] |
Ca2+ intracellular accumulation and/or decreased Ca2+ ATPase activity | [141,172,185,186,187,188,189,190,191] | [73,75,192,193] |
Decreased intracellular ATP level | [154,172] | [68,72,73,75,77,80,81,82,83,88,156,157,162,194,195,196,197,198,199,200,201,202,203,204] |
Elevated intra-RBC protein oxidation | [102,118,145,205,206,207,208,209,210,211,212] | [34,71,73,79,135,137,162,179,181,213,214,215,216,217,218,219,220,221,222,223,224,225,226,227,228,229,230,231,232,233] |
Elevated lipid peroxidation | [106,114,115,126,127,141,145,210,234,235,236,237,238,239] | [79,135,162,179,215,221,240,241] |
Elevated Poly Unsaturated Fatty Acid (PUFA) oxidation | [127,242] | [73,148,243] |
Decreased ATP release from RBC | [244,245,246,247] | [199,248,249] |
Decreased intra-RBC NADPH | [110,111,247] | [104] |
Decreased RBC deformability | [59,187,211,250,251,252,253,254,255,256,257,258,259,260,261,262,263,264,265,266,267,268] | [70,73,156,197,216,269,270,271,272,273,274,275,276,277] |
Elevated RBC adhesion | [278,279,280] | [275,281,282] |
Elevated RBC aggregability | [262,283,284,285,286] | [162,275,287] |
Elevated release of Extracellular vesicles (EVs) | [288] | [69,72,73,156,192,289,290,291,292,293,294,295] |
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Livshits, L.; Barshtein, G.; Arbell, D.; Gural, A.; Levin, C.; Guizouarn, H. Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions? Biomolecules 2021, 11, 992. https://doi.org/10.3390/biom11070992
Livshits L, Barshtein G, Arbell D, Gural A, Levin C, Guizouarn H. Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions? Biomolecules. 2021; 11(7):992. https://doi.org/10.3390/biom11070992
Chicago/Turabian StyleLivshits, Leonid, Gregory Barshtein, Dan Arbell, Alexander Gural, Carina Levin, and Hélène Guizouarn. 2021. "Do We Store Packed Red Blood Cells under “Quasi-Diabetic” Conditions?" Biomolecules 11, no. 7: 992. https://doi.org/10.3390/biom11070992