Emerging Contributions of Pluripotent Stem Cells to Reproductive Technologies in Veterinary Medicine
Abstract
:1. Introduction
2. “Old” and New Technologies for Embryo Production
Species | Old Technologies | New Technologies | References |
---|---|---|---|
Bovine | IVF, OPU, ICSI, and SCNT | Blastoid (EPSCs + TSCs) | [11,18] |
Porcine | IVF, ICSI, and SCNT | OLCs, SSCLCs, and PGCLCS | [17,21,22,36,37,38,39] |
Equine | IVF and ICSI | [19,26,27] | |
Mice | IVF | Blastoid (ESCs + TSCs, EPSCs + TSCs, and EPSCs), PGCLCs, xrOVARY, and rTESTES | [8,12,15,40,41,42] |
Human | IVF | Blastoid (naïve PSCs, EPSCs, and iPSCs), PGCLCs, and xrOVARY | [7,16,43,44,45,46] |
3. Production of Competent Gametes in Livestock
3.1. Germline Cells In Vivo
3.2. X Chromosome Inactivation (XCI)
3.3. Gametogenesis In Vitro
4. Animal Models and Translational Medicine
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Reference | Species | Description |
---|---|---|
[14] | Rabbit | The oocytes were matured in vivo, and the sperm was capacitated in the female reproductive tract. Fifteen live and healthy animals were born. |
[15] | Mice | The oocytes were obtained from the female’s oviduct, and the sperm was collected from the uterus of a mated female. The fetuses were 17 days old. |
[16] | Human | The oocyte was retrieved by laparoscopy, followed by in vitro fertilization. A healthy, normal child weighing 2.7 kg was born. |
[17] | Porcine | The oocytes were punctured from the follicles and then transferred to the oviduct of the female, which was artificially inseminated. The embryos continued to develop normally for up to 25 days. |
[18] | Bovine | The oocytes were surgically collected and fertilized in vitro, resulting in the birth of a 45 kg calf. |
[19] | Equine | The oocytes were matured in vivo and recovered from the stimulated dominant follicle, and the sperm was treated with calcium ionophore A23187. The pregnancy was brought to term with the birth of two foals. |
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de Castro, R.C.F.; Buranello, T.W.; Recchia, K.; de Souza, A.F.; Pieri, N.C.G.; Bressan, F.F. Emerging Contributions of Pluripotent Stem Cells to Reproductive Technologies in Veterinary Medicine. J. Dev. Biol. 2024, 12, 14. https://doi.org/10.3390/jdb12020014
de Castro RCF, Buranello TW, Recchia K, de Souza AF, Pieri NCG, Bressan FF. Emerging Contributions of Pluripotent Stem Cells to Reproductive Technologies in Veterinary Medicine. Journal of Developmental Biology. 2024; 12(2):14. https://doi.org/10.3390/jdb12020014
Chicago/Turabian Stylede Castro, Raiane Cristina Fratini, Tiago William Buranello, Kaiana Recchia, Aline Fernanda de Souza, Naira Caroline Godoy Pieri, and Fabiana Fernandes Bressan. 2024. "Emerging Contributions of Pluripotent Stem Cells to Reproductive Technologies in Veterinary Medicine" Journal of Developmental Biology 12, no. 2: 14. https://doi.org/10.3390/jdb12020014