Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective
Abstract
:1. The Canonical Wnt/β-Catenin Signaling Pathway
1.1. Wnt/β-Catenin Signaling Pathway
1.2. Wnt/β-Catenin Signaling in Development and Disease
2. Wnt/β-Catenin Signaling in Mammalian Intestinal Physiology and Pathology
3. The Drosophila Adult Gut: A Powerful Model for Studying Wnt Signaling
4. Wg Signaling in the Drosophila Gut: Development, Homeostasis, Regeneration, and Tumorigenesis
4.1. Wg Is Expressed at Major Compartmental Boundaries in the Adult Midgut
4.2. Graded Activation of Wg Signaling at Major Compartment Boundaries in the Drosophila Midgut
4.3. Wg Directs Pattern Formation during Drosophila Gut Development
4.3.1. Wg Signaling in Formation of the Adult Intestinal Midgut/Hindgut Boundary during Pupation
4.3.2. Wg Signaling in Formation of the Foregut/Midgut Boundary of the Adult Gut during Development
4.3.3. Wg Signaling in Embryonic and Larval Gut Development
4.4. Wg Signaling Regulates ISC Self-Renewal/Maintenance and Proliferation in the Drosophila Adult Gut during Homeostasis
4.5. Wg Signaling in Adult Midgut and Hindgut Regeneration Following Injury
4.6. Hyperactivation of Wg Signaling Due to Loss of Apc: Initiation and Progression of Tumorigenesis in the Drosophila Gut
4.6.1. Initiation of Intestinal Tumorigenesis upon Loss of Apc
4.6.2. Progression of Intestinal Tumorigenesis Following Apc Loss
5. The Drosophila Gut as a Powerful In Vivo Context to Test Novel Therapeutic Agents and Novel Wnt Pathway Components
5.1. At the Receptor Level: The Signalosome
5.2. In the Cytoplasm: Tankyrase
5.3. In the Nucleus: Earthbound and Erect Wing
6. Crosstalk between Wg Signaling and Other Signaling Pathways in the Drosophila Gut
7. Conclusions
8. Future Perspectives
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Tian, A.; Benchabane, H.; Ahmed, Y. Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective. J. Dev. Biol. 2018, 6, 8. https://doi.org/10.3390/jdb6020008
Tian A, Benchabane H, Ahmed Y. Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective. Journal of Developmental Biology. 2018; 6(2):8. https://doi.org/10.3390/jdb6020008
Chicago/Turabian StyleTian, Ai, Hassina Benchabane, and Yashi Ahmed. 2018. "Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective" Journal of Developmental Biology 6, no. 2: 8. https://doi.org/10.3390/jdb6020008