The Role of Apoptotic Signaling in Axon Guidance
Abstract
:1. Introduction
Drosophila Netrin-B Is a Neurotrophic Factor That Blocks Cell Death
2. The Apoptotic Machinery and Guidance Receptors
3. How Could Caspase Signaling Operate in Growth Cone Guidance?
4. Extracellular Modulation of Caspase Activity in the Growth Cone
5. Caspase Signaling at the Fly CNS Midline
6. Apoptotic Signaling in Axon Branching
7. Critical Experiments for the Activated Caspase Model
8. Conclusions
- Localized activation of caspases in the growth cone may modulate axon guidance.
- Axon attractants can promote cell survival, while repellents can promote cell death.
- Neurotrophic factor effects on axon guidance could be through caspase signaling.
- Based on an analogy with systems in which caspase signaling has non-apoptotic roles, we propose that the duration and intensity of caspase activation can modulate growth cone activity, while longer and stronger caspase activity can induce death.
- Crossing the CNS midline is associated with lower caspase activity.
- Correct wiring of the nervous system could result from the elimination of incorrectly navigating neurons due to increased activity of the cell death machinery.
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Kellermeyer, R.; Heydman, L.M.; Mastick, G.S.; Kidd, T. The Role of Apoptotic Signaling in Axon Guidance. J. Dev. Biol. 2018, 6, 24. https://doi.org/10.3390/jdb6040024
Kellermeyer R, Heydman LM, Mastick GS, Kidd T. The Role of Apoptotic Signaling in Axon Guidance. Journal of Developmental Biology. 2018; 6(4):24. https://doi.org/10.3390/jdb6040024
Chicago/Turabian StyleKellermeyer, Riley, Leah M. Heydman, Grant S. Mastick, and Thomas Kidd. 2018. "The Role of Apoptotic Signaling in Axon Guidance" Journal of Developmental Biology 6, no. 4: 24. https://doi.org/10.3390/jdb6040024