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Biomedicines
Volume 12
Issue 7
10.3390/biomedicines12071445
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels

by
Georgiana Ioana Potra Cicalău
1,
Olivia Andreea Marcu
2,
Timea Claudia Ghitea
3,*,
Gabriela Ciavoi
1,
Raluca Cristina Iurcov
1,
Corina Beiusanu
2,
Daniela Florina Trifan
4,
Laura Grațiela Vicaș
3 and
Mariana Ganea
3
1
Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania
2
Department of Preclinics, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania
3
Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania
4
Department of Clinical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410068 Oradea, Romania
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(7), 1445; https://doi.org/10.3390/biomedicines12071445
Submission received: 20 May 2024 / Revised: 15 June 2024 / Accepted: 26 June 2024 / Published: 28 June 2024
(This article belongs to the Section Microbiology in Human Health and Disease)
Review Reports Versions Notes

Abstract

Periodontal disease and diabetes often co-occur; both are characterized by chronic inflammation. This study aimed to investigate the anti-inflammatory effects of carvacrol and magnolol when incorporated into a periodontal hydrogel and topically applied to Wistar rats with diabetes-associated periodontal disease. Forty male albino Wistar rats were divided into four groups: PD (induced diabetes and periodontitis), PDC (induced diabetes and periodontitis treated with carvacrol), PDM (induced diabetes and periodontitis treated with magnolol), and PDCM (induced diabetes and periodontitis treated with both carvacrol and magnolol). Post treatment, gingival tissue samples were collected to measure levels of the pro-inflammatory cytokines IL-6 and TNF-α. The PDCM group exhibited significantly lower levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) compared to the PD group. The combined application of a periodontal hydrogel containing carvacrol and magnolol may significantly reduce gingival inflammation in rats with diabetes-associated periodontal disease.
Keywords: carvacrol; magnolol; periodontopathies; cytokines carvacrol; magnolol; periodontopathies; cytokines

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MDPI and ACS Style

Potra Cicalău, G.I.; Marcu, O.A.; Ghitea, T.C.; Ciavoi, G.; Iurcov, R.C.; Beiusanu, C.; Trifan, D.F.; Vicaș, L.G.; Ganea, M. Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels. Biomedicines 2024, 12, 1445. https://doi.org/10.3390/biomedicines12071445

AMA Style

Potra Cicalău GI, Marcu OA, Ghitea TC, Ciavoi G, Iurcov RC, Beiusanu C, Trifan DF, Vicaș LG, Ganea M. Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels. Biomedicines. 2024; 12(7):1445. https://doi.org/10.3390/biomedicines12071445

Chicago/Turabian Style

Potra Cicalău, Georgiana Ioana, Olivia Andreea Marcu, Timea Claudia Ghitea, Gabriela Ciavoi, Raluca Cristina Iurcov, Corina Beiusanu, Daniela Florina Trifan, Laura Grațiela Vicaș, and Mariana Ganea. 2024. "Study of Periodontal Bacteria in Diabetic Wistar Rats: Assessing the Anti-Inflammatory Effects of Carvacrol and Magnolol Hydrogels" Biomedicines 12, no. 7: 1445. https://doi.org/10.3390/biomedicines12071445

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