β-tricalcium phosphate (β-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that do** the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped β-TCP,
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β-tricalcium phosphate (β-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that do** the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped β-TCP, that is explained by their ability, on the one hand, to reduce cytotoxicity for cells of the human organism, on the other hand, to achieve a successful antibacterial effect. Sr, Cu-co-doped solid solutions of the composition Ca
9.5–xSr
xCu(PO
4)
7 was obtained by the method of solid-phase reactions. The Rietveld method of structural refinement revealed the presence of Sr
2+ ions in four crystal sites: M1, M2, M3, and M4. The M5 site is completely occupied by Cu
2+. Isomorphic substitution of Ca
2+ → (Sr
2+and Cu
2+) expands the concentration limits of the existence of the solid solution with the β-TCP structure. No additional phases were formed up to
x = 4.5 in Ca
9.5–xSr
xCu(PO
4)
7. Biocompatibility tests were performed on cell lines of human bone marrow mesenchymal stromal cells (hMSC), human fibroblasts (MRC-5) and osteoblasts (U-2OS). It was demonstrated that cytotoxicity exhibited a concentration dependence, along with an increase in osteogenesis and cell proliferation. Ca
9.5–xSr
xCu(PO
4)
7 powders showed significant inhibitory activity against pathogenic strains Escherichia coli and Staphylococcus aureus. Piezoelectric properties of Ca
9.5–xSr
xCu(PO
4)
7 were investigated. Possible ways to achieve high piezoelectric response are discussed. The combination of bioactive properties of Ca
9.5–xSr
xCu(PO
4)
7 renders them multifunctional materials suitable for bone substitutes.
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