The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review
Abstract
:1. Introduction
2. Materials and Methods
3. Results
- Applications of nanostructures in bone regeneration.
- b.
- Applications of nanostructures in soft tissue regeneration
4. Discussion
- Delivery of medicines:
- 2.
- Soft tissue and bone regeneration
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Author [Reference] | Clearly Stated Aims/ Objectives | Detailed Explanation of Sample Size Calculation | Detailed Explanation of Sampling Technique | Details of Comparison Group | Detailed Explanation of Methodology | Operator Details | Randomization | Method of Measurement of Outcome | Outcome Assessor Details | Blinding | Statistical Analysis | Presentation of Results | Final Score |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Chen P. [11] | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 0 | X | 2 | 2 | 60% |
Hokmabad VR. [12] | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 0 | X | 2 | 2 | 60% |
Ni C. [13] | 2 | 1 | 1 | 2 | 2 | 1 | 2 | 2 | 0 | X | 2 | 2 | 68% |
Moonesi Rad R. [14] | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | X | 2 | 2 | 73% |
Boda SK. [15] | 2 | 0 | 2 | 2 | 2 | 0 | 1 | 2 | 0 | X | 2 | 2 | 68% |
Martínez-Sanmiguel JJ. [16] | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | X | 2 | 2 | 73% |
Xue Y. [17] | 2 | 1 | 1 | 1 | 2 | 0 | 1 | 2 | 0 | X | 2 | 2 | 63% |
Ou Q. [18] | 2 | 1 | 2 | 1 | 2 | 0 | 1 | 2 | 0 | X | 2 | 2 | 68% |
Covarrubias C. [19] | 2 | 1 | 1 | 1 | 2 | 0 | 1 | 2 | 0 | X | 2 | 2 | 63% |
**a Y. [20] | 2 | 1 | 1 | 1 | 2 | 0 | 1 | 2 | 0 | X | 2 | 2 | 63% |
Boda SK. [21] | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | X | 2 | 2 | 73% |
Liu X. [22] | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | X | 2 | 2 | 73% |
Ghavimi MA. [23] | 2 | 2 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | X | 1 | 2 | 73% |
Pang Z. [24] | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 0 | X | 2 | 2 | 60% |
Lam LRW. [25] | 2 | 1 | 1 | 1 | 2 | 1 | 0 | 2 | 1 | X | 2 | 2 | 68% |
Ma L. [26] | 2 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | X | 2 | 2 | 73% |
**e D. [27] | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 1 | X | 2 | 2 | 63% |
Zhang Y. [28] | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 0 | X | 2 | 2 | 60% |
Su T. [29] | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 0 | X | 2 | 2 | 60% |
Kim SY. [30] | 2 | 1 | 1 | 1 | 2 | 0 | 0 | 2 | 0 | X | 2 | 2 | 60% |
Shi Z. [31] | 2 | 1 | 1 | 1 | 2 | 1 | 0 | 2 | 1 | X | 2 | 2 | 68% |
Author, Year, [Reference] | Study Type and Design | Study Objectives | Nanostructure Type | New Techniques for Obtaining Nanostructures | Applications in Dentistry | Outcomes |
---|---|---|---|---|---|---|
Chen P. et al., 2018 [11] | In vitro | - a new collagen membrane coated with silver nanoparticle (AgNP) | - AgNP - coated collagen membrane | - preparation of silver-coated collagen membrane - sonication coating - sputtering coating | - antibacterial and anti-inflammatory capacity | - With only minimal cytotoxicity, the collagen coated with AgNP demonstrated the ability to strengthen the membrane’s antibacterial and anti-inflammatory properties. |
Hokmabad V.R. et al., 2019 [12] | In vitro | - obtain new scaffolds of ethyl cellulose-grafted-poly (ε-caprolactone)(EC-g-PCL) obtained by a new manufacturing method | - the new EC-g-PCL/alginate scaffolds with different contents of nanohydroxyapatite | - synthesis, preparation, and characterization of the scaffolds | - tissue and bone engineering | - the hDPSCs exhibited strong adhesion, proliferation, and differentiation on EC-g-PCL/alginate scaffolds combined with nanohydroxyapatite. |
Ni C. et al., 2019 [13] | In vitro and in vivo on an animal model | - the potential therapeutic application of gold nanoparticles (AuNPs)—the optimum size | - AuNPs | - not applicable | - tissue and bone engineering | - The 45 nm AuNPs might control the early inflammatory response of periodontal tissues, in addition to directly modulating hPDLCs. |
Moonesi Rad R. et al., 2019 [14] | In vitro | – a new asymmetric bilayered membrane | - boron-modified bioactive glass (7B-BG) | - preparation of the bilayered membranes by the electrospinning method and characterization | - bone regeneration | - for GBR applications, a functionally graded bilayered membrane was effectively created. |
Boda S.K. et al., 2019 [15] | In vitro and in vivo on a animal model | - the potential of mineralized nanofiber segments coupled with calcium-binding bone morphogenetic protein 2 (E7-BMP-2 peptides) | - mineralized nanofiber segments coupled with E7-BMP-2 peptides | - electrospinning -mineralization - characterization | - bone regeneration | - A potential substitute for bone tissue regeneration is provided by the nanofiber fragments. |
Martínez-Sanmiguel J.J. et al., 2019 [16] | In vitro | - fabrication of Hydroxyapatite/silver (HA/Ag) nanocomposites with better antimicrobial efficiency and anti-inflammatory properties | - HA/Ag nanocomposites | - synthesis and characterization of HA/Ag nanocomposites | - antimicrobial and anti-inflammatory capacity | - All of the HA/Ag doses examined (250–7 lg/mL) exhibited antibacterial action against E. Coli and antifungal efficacy against Candida albicans. |
Xue Y. et al., 2019 [17] | In vitro and in vivo on a animal model | - investigation of the optimal composite ratio of these three materials for periodontal tissue regeneration | - the mixture of poly(lactic-co-glycolic acid)/chitosan/Ag nanoparticles | - production of nanoparticles of chitosan (CS), poly(lactic-co-glycolic acid) (PLGA), and silver | - tissue regeneration | - The ideal ratio and cell mineralization were facilitated by the nPLGA/nCS/nAg combination, which exhibited no cytotoxicity, as follows: 3:7 nPLGA/nCS and 50 µg/mL nAg ratios. |
Ou Q. et al., 2019 [18] | In vitro and in vivo on an animal model | - a new zein/gelatin/nanohydroxyapatite (zein/gelatin/nHAp) nanofibrous membranes | zein/gelatin/nanohydroxyapatite nanofibrous membranes (zein/gelatin/nHAp) | - the electrospun zein/gelatin/nHAp nanofibers | -tissue and bone engineering | - The zein/gelatin/nHAp nanofibers help hPDLSCs adhere, proliferate, and differentiate into osteoblasts. |
Covarrubias C. et al., 2019 [19] | In vitro and in vivo on a animal model | - a new method of preparation of bionanocomposite scaffolds | - bionanocomposite scaffolds based on aliphatic polyurethane (PU) and bioactive glass nanoparticles (nBG) | - the one-step in situ polymerization method | - bone regeneration | - PU nanocomposite scaffolds that support bone regeneration can be produced using a one-step in situ preparation technique when nBG particles are present. |
**a Y. et al., 2019 [20] | In vitro | - the effects of the new composite on bone matrix formation and osteogenic differentiation | - iron oxide nanoparticle-calcium phosphate cement (CPC + IONP) | - fabrication and testing of CPC + IONP scaffold | - bone regeneration | - Incorporating IONP into CPC scaffold remarkably enhanced the spreading, osteogenic differentiation, and bone mineral synthesis of stem cells. |
Boda S.K. et al., 2020 [21] | In vitro | - the presentation of dual soft mucosal and hard bone/enamel tissue adhesive nanofiber membranes | - dual oral tissue adhesive nanofiber membranes | - fabrication and characterization of the oral dual tissue adhesive | - tissue and bone engineering | - fabrication of the chitosan-based nanofiber membranes with dual adhesion to soft and hard tissue surfaces and pH-controlled delivery of antimicrobial agents, antibiotics, and peptides |
Liu X. et al., 2020 [22] | In vitro and in vivo on an animal model | - getting a time-programmed multi-drug releasing system | - core-shell nanofiber membrane | - preparation and characterization of the core-shell nanofiber membrane | - delivery of medicines | - dual-drug core-shell nanofiber membrane with the capacity to control the release order of different drugs |
Ghavimi M.A. et al., 2020 [23] | In vitro and in vivo | - development of an asymmetric guided bone regeneration (GBR) membrane benefiting from curcumin and aspirin | - nanofibrous asymmetric collagen/curcumin membrane | - fabrication using electrospinning technique and characterization of asymmetric membrane | - tissue and bone engineering | - The prepared membrane acts as osteoinductive material to promote the new bone formation. |
Pang Z. et al., 2021 [24] | In vitro and in vivo on an animal model | - development of a bioactive coating on PEEK and investigate the effects of coating on cellular response | - Nanostructured coating of non-crystalline tantalum pentoxide (TP) on polyetheretherketone (PEEK) (PKTP). | - preparation and characterization of TP coating on PEEK by utilizing vacuum evaporation | - tissue regeneration | - Both RBMS cells and HGE cells responded strongly when exposed to PKTP with TP coating, improving surface performances. |
Lam L.R.W. et al., 2021 [25] | In vitro | - development of a multifunctional core-shell nanofiber membrane | - core-shell nanofibers with encapsulated enamel matrix | - coaxial electrospinning and characterization of core-shell nanofibers. | - tissue regeneration | - Core-shell nanofiber membranes may improve outcomes in periodontal regenerative therapy. |
Ma L. et al., 2021 [26] | In vitro and in vivo on a animal model | - The influence of the dosage of berberine (BBR) (25, 50, 75, and 100 μg/mL) on scaffold morphology, cell behavior, and in vivo bone defect repair were systematically studied. | - Berberine-releasing scaffold | - preparation using electrospinning technology and characterization of scaffolds | - tissue regeneration | - A BBR/PCL/COL electrospun scaffold accelerates the bone defect repair process. |
**e D. et al., 2021 [27] | In vitro | - construction of a submicro-nano structure on polyetheretherketone (PEEK) by femtosecond laser (FSL) | - submicro-nano structures on polyetheretherketone PEEK | - tissue/bone regeneration | - The 80FPK and 160FPK with submicro-nano structures significantly improved surface performances and remarkably stimulated the adhesion and proliferation of GE cells. | |
Zhang Y. et al., 2021 [28] | In vitro | - the effect of gold nanoparticles (AuNPs) on osteogenic differentiation of periodontal ligament stem cell (PDLSC) sheets | - gold nanoparticles (AuNPs) | - synthesis and characterization of AuNPs | - bone regeneration | - AuNPs enhance the osteogenesis of PDLSC sheets by activating autophagy. |
Su T. et al., 2022 [29] | In vitro | - a new composite multifunctional coating (PHG) to improve soft tissue sealing | - a composite multifunctional coating (PHG) prepared using gelatin and polydopamine/hydroxyapatite nanoparticles (PDA-HA) | - preparation of PDA-HA-Gelatin@Ti (PHG@Ti) and surface characterization | - bone and tissue regeneration | - The proposed PHG coating may promote soft tissue sealing and bone bonding. |
Kim S.Y. et al., 2022 [30] | In vitro and in vivo on an animal model | - to reduce the possibility of surgical failure caused by microbial infection | - manuka oil in a biocompatible nanostructure surface on Ti | - pure titanium with a 0.1 mm thickness coated with 0.1%, 0.5%, 1%, and 2% manuka oil | - antibacterial and anti-inflammatory capacity | - strong inhibitory effects against several pathogenic bacteria |
Shi Z. et al., 2023, [31] | In vitro and in vivo on an animal model | - fabrication of FHCS hydrogels to treat the bone wound and to bridge the newborn bone tissue | - thermo-dependent hydrogel, named as FHCS | - fabrication and characterizations of the FHCS hydrogel | - tissue and bone regeneration | - An FHCS-5 hydrogel enhanced osteogenesis most significantly in the animal model of a critical-sized calvarial bone defect. |
Huang A.C. et al., 2023 [32] | Animal: rats | - the therapeutic effect of nuclear factor-kappa B (NF-κB) decoy oligodeoxynucleotide (ODNs) on the extraction sockets of Wistar/ST rats | - NF-κB decoy s ODNs loaded poly(lactic-co-glycolic acid) nanospheres (PLGA-NfDs) | - preparation of decoy ODN-loaded PLGA nanosphere | - tissue and bone engineering | - The use of this nanostructure can prevent early acute inflammation in a tooth extraction socket, with the potential to accelerate new bone formation. |
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Muresan, G.C.; Boca, S.; Lucaciu, O.; Hedesiu, M. The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review. Biomimetics 2024, 9, 348. https://doi.org/10.3390/biomimetics9060348
Muresan GC, Boca S, Lucaciu O, Hedesiu M. The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review. Biomimetics. 2024; 9(6):348. https://doi.org/10.3390/biomimetics9060348
Chicago/Turabian StyleMuresan, Giorgiana Corina, Sanda Boca, Ondine Lucaciu, and Mihaela Hedesiu. 2024. "The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review" Biomimetics 9, no. 6: 348. https://doi.org/10.3390/biomimetics9060348