Hedgehog Signaling: Advances in Development and Cancer—Second Edition
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 January 2025 | Viewed by 17
Special Issue Editor
Interests: cell signaling; development; cell culture; drosophila
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This is the expanded second edition of ‘Hedgehog Signaling: Advances in Development and Cancer’, the first edition of which led to the publication of five papers.
Thirty years ago, in 1992, the Drosophila hedgehog (hh) gene was independently cloned by the research teams of Jym Mohler, Philip Beachy, Thomas Kornberg, and Saigo Kaoru. Following this discovery, three classes of vertebrate hh genes were identified: Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh). We now know that the Hh signaling pathway patterns a variety of organs and tissues in metazoan embryos. Defective Hh signaling during development, thus, leads to patterning defects, such as disrupted segmentation in Drosophila, holoprosencephaly, and other malformations in humans. Postembryonically, the Hh pathway also functions homeostatically in tissue maintenance and regeneration processes, acting on tissue stem or progenitor cells. Therefore, the postembryonic dysregulation of Hh pathway activity can result in proliferative conditions, such as malignant tumors or tissue degeneration.
In this Special Issue, in recognition of it being thirty years since the discovery of the hh gene, we invite you to advance our current knowledge on Hh signaling by contributing review or original research articles describing mechanistic insights at the molecular, cellular, or organismal levels, as well as those of translational value.
Dr. **aoyan Zheng
Guest Editor
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Keywords
- hedgehog signaling
- hh gene
- smoothened (SMO)
Related Special Issue
- Hedgehog Signaling: Advances in Development and Cancer in Cells (5 articles)
