Spleen: Crossroad between Immune System, Metabolic Asset and Endocrine Function 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 15 November 2024 | Viewed by 45
Special Issue Editor
Interests: nonalcoholic fatty liver disease; metabolic syndrome; obesity; atherosclerosis and NAFLD; PCOS and NAFLD; HCV-related chronic hepatitis; HCV-related arthritis; therapy of liver cirrhosis; portal hypertension; hepatic encephalopathy; imaging-ultrasonography of liver and spleen; psoriatic arthritis and NAFLD; cytokines in obesity
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Special Issue Information
Dear Colleagues,
This Special Issue is a continuation of the previous Special Issue titled “Spleen: Crossroad between Immune System, Metabolic Asset and Endocrine Function” (https://mdpi.longhoe.net/journal/ijms/special_issues/spleen).
Due to the view that the “spleen is useless”, research on this organ has lagged behind that of other organs. Since 1952, when King and Schumacker reported overwhelming post-splenectomy infection, there has been growing recognition of the importance of the spleen in the human body. On the other hand, physicians often encounter spleen enlargement, i.e., splenomegaly, which is almost always a consequence of other disorders. Hypersplenism is a secondary process that can arise from splenomegaly of almost any cause. In recent years, following in-depth studies of spleen organization and structure, cell function, secretion, and innervations, a better understanding of the function of the spleen has been gained. It was initially accepted that the spleen not only filters blood but is also an important regulation center of the body’s immune–metabolic–endocrine network. However, several questions have arisen: Is the spleen a player or a bystander, and what are the roles of the cytokines, adipokines/growth factors, and neurotransmitters involved in this complex mechanism? Furthermore, what is the contribution of the spleen to obesity-related diseases? Finally, does the spleen contribute to the complex network between trace elements or environmental particulate matter and immunity?
We welcome contributions related to these areas for publication in this Special Issue. Original research articles as well as reviews and communications are encouraged.
Prof. Dr. Giovanni Tarantino
Guest Editor
Manuscript Submission Information
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Keywords
- cytokines
- neurotransmitters
- hormones/growth factors
- vitamin D and spleen
- mechanisms linking spleen and obesity-related diseases (NAFLD, OSAS, PCOS)
- trace elements/immunity and spleen
- environmental particulate matter/immunity and spleen
- spleen-organ axes
