Clinical Advances in Malaria

Dear Colleagues,

Malaria control figures are poor, falling far short of the WHO's Global Technical Strategy for Malaria 2016–2030 (GTSM) targets of reducing malaria incidence and mortality by at least 40% by 2020, 75% by 2025 and 90% by 2030, based on the 2015 baseline data. Indeed, the incidence figures were 58.7 in 2020 and 58.4 in 2022, for a reference value of 59.8 cases per 1,000 inhabitants in 2015, and those for mortality 15.2 and 14.3 for a reference value of 15.2 per 100,000 inhabitants. More directly, malaria has been estimated to be responsible for 249 [225–278] million cases and 608,000 [566,000–738,000] deaths in 2022. The endemic is still active in 84 countries worldwide plus French Guyana, but is now essentially African, accounting for 93.6% of cases and 95% of deaths. It also concerns international travelers. As such, all countries in the world are affected. With potential vectors still present, it is likely to reappear in areas where it has been eliminated, as in Greece between 2009 and 2012.

This is a worrying situation in a world that is particularly unstable politically, ecologically and climatically. The specter of a return to a much more dramatic malaria epidemic is looming and is of the utmost concern to health authorities.

The general aim of this Special Issue is to take an overview of the current situation in the fight against malaria worldwide, and to discuss the diagnostic and therapeutic means, as well as the human and financial resources that need to be mobilized to control or eliminate/eradicate malaria. More specifically, we will examine:

- The particularities of malaria epidemiology in sub-Saharan Africa, and why malaria control there is so complicated;

- Mosquito resistance to insecticides and parasite resistance to drugs;

- Biological diagnosis of malaria and technical developments that could have a positive impact on global control;

- New therapeutic approaches, in particular the role of vaccines and monoclonal antibodies in the global fight against malaria.

Dr. Marc Thellier
Guest Editor

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• malaria
• diagnosis
• treatment
• vaccination
• resistance
• epidemiology
• public health