Microbiomes and Integrated Multi-omics in Health and Disease

Dear Colleagues,

The intricate and dynamic relationship between hosts and their associated microbiomes has emerged as a critical factor in understanding the pathogenesis and progression of various human diseases. Recent advancements in high-throughput omics technologies have enabled a more comprehensive understanding of this complex system, providing novel insights into the molecular mechanisms underlying host–microbiome interactions and their influence on health and disease.

Genomic sequencing has enabled the comprehensive characterization of microbial communities and their functional capabilities within the host environment. Transcriptomic analysis has revealed dynamic changes in gene expression patterns, shedding light on the signaling networks and pathways involved in host–microbiome crosstalk. Proteomic studies have identified the key proteins mediating various processes, including immune responses and metabolic exchanges. Furthermore, metabolomic profiling has elucidated the metabolic interactions and signaling molecules that shape the host–microbiome symbiosis and its impact on physiology and disease progression. The integration of these powerful omics approaches has provided a holistic understanding of the complex and multifaceted host–microbiome system, paving the way for develo** targeted interventions and personalized healthcare strategies to address various health conditions.

This collection aims to showcase cutting-edge research employing integrative multi-omics approaches to elucidate the complex host–microbiome interactions in health and disease. We invite submissions that explore the application of genomics, transcriptomics, proteomics, metabolomics, and other emerging omics techniques to unravel the underlying mechanisms governing host–microbiome symbiosis and how this relationship collectively shapes disease susceptibility, progression, and outcomes. We hope that these discoveries will provide new perspectives and valuable insights to inform the development of more effective therapeutic and intervention strategies.

Some topics of interest include, but are not limited to, the following:

• Integrated multi-omics studies elucidating the molecular cross-talk between hosts and their microbiomes;
• Identification of microbial and host-derived biomarkers for disease prediction, diagnosis, and monitoring;
• Novel computational and bioinformatic tools for integrative host–microbiome omics analysis;
• Translational applications of integrated host–microbiome omics in personalized medicine and targeted therapeutic interventions;
• Methodological advancements in sample preparation, data acquisition, and multi-omics data integration;
• Challenges and solutions in the interpretation of complex host–microbiome omics datasets;
• Application of machine learning and artificial intelligence for multi-omics data analysis;
• Case studies demonstrating the potential of multi-omics approaches to understand health, disease, and host–microbiome interactions;
• Unraveling the host–microbiome interactome through multi-omics approaches;
• Ethical and regulatory considerations in the application of host–microbiome omics for human health.

Prof. Dr. Pabulo H. Rampelotto
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• bioinformatics
• biomarker discovery
• integrative data analysis
• interactome
• host–microbiome interactions
• omics datasets
• omics technologies
• metabolomics
• metagenomics
• metaproteomics
• microbiome-associated diseases
• molecular crosstalk
• multi-omics
• personalized medicine
• translational applications