The Impact of Metal Complexes with Active Small Molecules in Biological Systems
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Inorganic Chemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 37
Special Issue Editors
Interests: coordination chemistry; polyphenols; coordination compounds; metalloproteins; oxidative stress; iron; free radicals; spectroscopy; biochemistry; bioinorganic chemistry; DNA interactions; antioxidants; antioxidant assays; inorganic biochemistry; inorganic chemistry; coordination chemistry and metal complexes; lanthanide; synthesis; electronic structure; inorganic synthesis; organometallics; circular dichroism; electron spin resonance spectroscopy; flavonoids; apoptosis; organic synthesis; nitric oxide; structural biology; phenolic compounds; thiols; genotoxicity
Special Issues, Collections and Topics in MDPI journals
Interests: radiochemistry; inorganic chemistry; chemical analytics; cellular response; cytotoxicity; radiobiology; radiopharmacy; targeting chemical compounds to the tumor phenotype
Special Issue Information
Dear Colleagues,
This Issue will focus on the newest findings on metal complexes with active small molecules (M-ASM) in biological systems. This publication will discuss all aspects of signalling and regulatory functions of metal complexes with active small molecules, including redox status modulation and anti/pro-oxidant activities, protein induction and inhibition. Tentative subjects include (but are not limited to) the following:
- Turnover, metabolism, and interconversions of metal complexes with active small molecules (M-ASMs):
- Synthesis: How M-ASMs are produced in cells, including the enzymes and metabolic pathways involved.
- Degradation: How M-ASMs are broken down in cells, including the enzymes and metabolic pathways involved.
- Interconversions: How M-ASMs are converted into different forms, including the enzymes and metabolic pathways involved.
- Signaling and regulatory functions of M-ASMs:
- Metallic cellular targets of ASMs.
- Metal cofactor-driven signaling mechanisms.
- Oxidation state-related cellular aspects of M-ASM-dependent signaling.
- M-ASM-related cancer-signaling pathways.
- Correlation between the structural features of ASMs and their metal complexes with their biological activity:
- How geometry and ligand properties of an ASM can affect its interactions with metal ions and other molecules in the cell.
- How the periodic properties and oxidation state of the metal ion can affect the activity of the ASM-metal complex.
- How the structure of the ASM-metal complex can affect its specificity for different cellular targets.
- M-ASM potential applications in cellular therapeutics:
- How M-ASMs can be used to develop new drugs and therapies for diseases such as cancer and Alzheimer's disease.
- How M-ASMs can be used to develop new strategies for DNA-targeted therapy.
- How M-ASMs can be used to develop new tools for diagnosing and monitoring diseases.
Both review and original papers are welcome. Authors are encouraged to suggest any other aspects of the M-ASM-related cellular activity, according to their knowledge and expertise.
Dr. Hanna Lewandowska
Dr. Karolina E. Wójciuk
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metal complexes
- active small molecules
- biological systems
- signaling and regulatory functions
- DNA-targeted therapy
- new drugs and therapies
- cellular therapeutics
