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Volume 29
Issue 13
10.3390/molecules29133123
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Host-Guest Complexes of Flavanone and 4′-Chloroflavanone with Naturals and Modified Cyclodextrin: A Calorimetric and Spectroscopy Investigations

by
Artur Stepniak
*,
Marta Biernacka
,
Magdalena Malecka
and
Bartlomiej Palecz
Unit of Biophysical Chemistry, Department of Physical Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-230 Lodz, Poland
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(13), 3123; https://doi.org/10.3390/molecules29133123
Submission received: 28 May 2024 / Revised: 20 June 2024 / Accepted: 25 June 2024 / Published: 30 June 2024
(This article belongs to the Special Issue Unlocking the Formulation Potential of Cyclodextrins and Their Derivatives—Volume II)
Versions Notes

Abstract

The aim of the research was to investigate and compare the interaction between flavanones (flavanone, 4-chloro-flavanone) with potential anticancer activity and selected cyclodextrins. Measurements were made using calorimetric (ITC, DSC) and spectrophotometric (UV-Vis spectroscopy, FT-IR, 1H NMR) methods. The increase in the solubility in aqueous medium caused by the complexation process was determined by the Higuchi-Connors method. As a result of the study, the stoichiometry and thermodynamics of the complexation reaction were determined. The formation of stable inclusion complexes at a 1:1 M ratio between flavanone and 4-chloroflavanone and the cyclodextrins selected for research was also confirmed.
Keywords: solubility enhancement; cyclodextrin; inclusion complex; Higuchi-Connors method; isothermal titration calorimetry; DSC; flavanone solubility enhancement; cyclodextrin; inclusion complex; Higuchi-Connors method; isothermal titration calorimetry; DSC; flavanone

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MDPI and ACS Style

Stepniak, A.; Biernacka, M.; Malecka, M.; Palecz, B. Host-Guest Complexes of Flavanone and 4′-Chloroflavanone with Naturals and Modified Cyclodextrin: A Calorimetric and Spectroscopy Investigations. Molecules 2024, 29, 3123. https://doi.org/10.3390/molecules29133123

AMA Style

Stepniak A, Biernacka M, Malecka M, Palecz B. Host-Guest Complexes of Flavanone and 4′-Chloroflavanone with Naturals and Modified Cyclodextrin: A Calorimetric and Spectroscopy Investigations. Molecules. 2024; 29(13):3123. https://doi.org/10.3390/molecules29133123

Chicago/Turabian Style

Stepniak, Artur, Marta Biernacka, Magdalena Malecka, and Bartlomiej Palecz. 2024. "Host-Guest Complexes of Flavanone and 4′-Chloroflavanone with Naturals and Modified Cyclodextrin: A Calorimetric and Spectroscopy Investigations" Molecules 29, no. 13: 3123. https://doi.org/10.3390/molecules29133123

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