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Antibiotics
Special Issues
Combating Biofilm-Related Infections: Novel Therapeutics and Strategies
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Combating Biofilm-Related Infections: Novel Therapeutics and Strategies

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiofilm Strategies".

Deadline for manuscript submissions: 15 September 2024 | Viewed by 4615

Special Issue Editor

Dr. Ali Pormohammad

E-Mail Website
Guest Editor
Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, AB T2N 1N4, Canada
Interests: antimicrobial resistance; biofilm; host-pathogens interactions; molecular microbiology, metal-based antimicrobials; wound infection; wound healing; bacterial omics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As a Guest Editor for Antibiotics, I am honored to introduce the Special Issue, titled "Combating Biofilm-Related Infections: Novel Therapeutics and Strategies". This Special Issue explores cutting-edge research on biofilms, as well as complex microbial communities that challenge traditional antimicrobial therapies, leading to treatment failures and increased morbidity.

In this compilation, esteemed researchers and practitioners present groundbreaking research articles and reviews covering various disciplines, including microbiology, pharmacology, biotechnology, and clinical medicine. Topics include emerging antimicrobial agents, biofilm-specific drug delivery systems, immunomodulatory approaches, quorum sensing targeting, natural products as anti-biofilm agents, combination therapies, and diagnostic tools for biofilm-related infections.

We believe that the findings presented here will significantly impact the field of infectious diseases, offering promising avenues for therapeutic intervention against biofilm-related infections. Our sincere gratitude goes to all the authors, reviewers, and editorial team members for their invaluable contributions in making this Special Issue a comprehensive resource for researchers, clinicians, and policymakers. We hope the shared knowledge will inspire further investigations and improve patient outcomes in the fight against biofilm-related infections.

Dr. Ali Pormohammad
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

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11 pages, 3631 KiB  
Article
Chestnut Honey Is Effective against Mixed Biofilms at Different Stages of Maturity
by Regina Koloh, Viktória L. Balázs, Lilla Nagy-Radványi, Béla Kocsis, Erika Beáta Kerekes, Marianna Kocsis and Ágnes Farkas
Antibiotics 2024, 13(3), 255; https://doi.org/10.3390/antibiotics13030255 - 13 Mar 2024
Viewed by 1661
Abstract
The irresponsible overuse of antibiotics has increased the occurrence of resistant bacterial strains, which represents one of the biggest patient safety risks today. Due to antibiotic resistance and biofilm formation in bacteria, it is becoming increasingly difficult to suppress the bacterial strains responsible [...] Read more.
The irresponsible overuse of antibiotics has increased the occurrence of resistant bacterial strains, which represents one of the biggest patient safety risks today. Due to antibiotic resistance and biofilm formation in bacteria, it is becoming increasingly difficult to suppress the bacterial strains responsible for various chronic infections. Honey was proven to inhibit bacterial growth and biofilm development, offering an alternative solution in the treatment of resistant infections and chronic wounds. Our studies included chestnut honey, valued for its high antibacterial activity, and the bacteria Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and S. epidermidis, known to form multi-species biofilm communities. Minimum inhibitory concentrations (MIC) of chestnut honey were determined for each bacterial strain. Afterwards, the mixed bacterial biofilms were treated with chestnut honey at different stages of maturity (incubation times: 2, 4, 6, 12, 24 h). The extent of biofilm inhibition was measured with a crystal violet assay and demonstrated by scanning electron microscopy (SEM). As the incubation time increased and the biofilm became more mature, inhibition rates decreased gradually. The most sensitive biofilm was the combination MRSA-S. epidermidis, with a 93.5% inhibition rate after 2 h of incubation. Our results revealed that chestnut honey is suitable for suppressing the initial and moderately mature stages of mixed biofilms. Full article
(This article belongs to the Special Issue Combating Biofilm-Related Infections: Novel Therapeutics and Strategies)
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Review

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16 pages, 3291 KiB  
Review
Medical Device-Associated Infections Caused by Biofilm-Forming Microbial Pathogens and Controlling Strategies
by Akanksha Mishra, Ashish Aggarwal and Fazlurrahman Khan
Antibiotics 2024, 13(7), 623; https://doi.org/10.3390/antibiotics13070623 - 4 Jul 2024
Viewed by 642
Abstract
Hospital-acquired infections, also known as nosocomial infections, include bloodstream infections, surgical site infections, skin and soft tissue infections, respiratory tract infections, and urinary tract infections. According to reports, Gram-positive and Gram-negative pathogenic bacteria account for up to 70% of nosocomial infections in intensive [...] Read more.
Hospital-acquired infections, also known as nosocomial infections, include bloodstream infections, surgical site infections, skin and soft tissue infections, respiratory tract infections, and urinary tract infections. According to reports, Gram-positive and Gram-negative pathogenic bacteria account for up to 70% of nosocomial infections in intensive care unit (ICU) patients. Biofilm production is a main virulence mechanism and a distinguishing feature of bacterial pathogens. Most bacterial pathogens develop biofilms at the solid-liquid and air-liquid interfaces. An essential requirement for biofilm production is the presence of a conditioning film. A conditioning film provides the first surface on which bacteria can adhere and fosters the growth of biofilms by creating a favorable environment. The conditioning film improves microbial adherence by delivering chemical signals or generating microenvironments. Microorganisms use this coating as a nutrient source. The film gathers both inorganic and organic substances from its surroundings, or these substances are generated by microbes in the film. These nutrients boost the initial growth of the adhering bacteria and facilitate biofilm formation by acting as a food source. Coatings with combined antibacterial efficacy and antifouling properties provide further benefits by preventing dead cells and debris from adhering to the surfaces. In the present review, we address numerous pathogenic microbes that form biofilms on the surfaces of biomedical devices. In addition, we explore several efficient smart antiadhesive coatings on the surfaces of biomedical device-relevant materials that manage nosocomial infections caused by biofilm-forming microbial pathogens. Full article
(This article belongs to the Special Issue Combating Biofilm-Related Infections: Novel Therapeutics and Strategies)
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23 pages, 5545 KiB  
Review
Emerging Issues and Initial Insights into Bacterial Biofilms: From Orthopedic Infection to Metabolomics
by Rasoul Mirzaei, Davide Campoccia, Stefano Ravaioli and Carla Renata Arciola
Antibiotics 2024, 13(2), 184; https://doi.org/10.3390/antibiotics13020184 - 13 Feb 2024
Cited by 2 | Viewed by 1900
Abstract
Bacterial biofilms, enigmatic communities of microorganisms enclosed in an extracellular matrix, still represent an open challenge in many clinical contexts, including orthopedics, where biofilm-associated bone and joint infections remain the main cause of implant failure. This study explores the scenario of biofilm infections, [...] Read more.
Bacterial biofilms, enigmatic communities of microorganisms enclosed in an extracellular matrix, still represent an open challenge in many clinical contexts, including orthopedics, where biofilm-associated bone and joint infections remain the main cause of implant failure. This study explores the scenario of biofilm infections, with a focus on those related to orthopedic implants, highlighting recently emerged substantial aspects of the pathogenesis and their potential repercussions on the clinic, as well as the progress and gaps that still exist in the diagnostics and management of these infections. The classic mechanisms through which biofilms form and the more recently proposed new ones are depicted. The ways in which bacteria hide, become impenetrable to antibiotics, and evade the immune defenses, creating reservoirs of bacteria difficult to detect and reach, are delineated, such as bacterial dormancy within biofilms, entry into host cells, and penetration into bone canaliculi. New findings on biofilm formation with host components are presented. The article also delves into the emerging and critical concept of immunometabolism, a key function of immune cells that biofilm interferes with. The growing potential of biofilm metabolomics in the diagnosis and therapy of biofilm infections is highlighted, referring to the latest research. Full article
(This article belongs to the Special Issue Combating Biofilm-Related Infections: Novel Therapeutics and Strategies)
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