Developmental Origins of Health and Disease: Antioxidants as Strategy for Prevention and Treatment
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 31 December 2024 | Viewed by 30
Special Issue Editors
Interests: fetal programming; hypertension; oxidative stress biomarkers; nutrition; confocal microscopy
Special Issues, Collections and Topics in MDPI journals
Interests: breast milk; inflammation; prematurity; fetal programming; oxidative status; obstetrical complications; pregnant physiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Disease development originates early in life, with mounting evidence highlighting the detrimental impact of adverse fetal environments on future health. Exposure to nutritional imbalances, hypoxia, toxic substances, obstetric complications, and psychological stress during pregnancy are well-documented to yield negative consequences for the offspring. These stressors exert their influence from the periconceptional period through the first 1000 days of life, underscoring their widespread reach.
Oxidative stress emerges as a common thread linking adverse early-life environments to disease development. Disruptions in redox equilibrium, stemming from either excessive oxidant production or inadequate antioxidant defenses, have been observed in humans and experimental animals exposed to these stressors during critical developmental windows. Oxidative stress contributes to germline damage, obstetric complications, and prematurity-related morbidity and underlies many common programmed diseases. Yet, the molecular changes tying these associations together remain largely unknown, including the mechanisms through which reactive oxygen species (ROS) and other oxidants modulate specific genes and their interplay with epigenetic modifications. Conversely, endogenous antioxidants sometimes prove insufficient, prompting an exploration into potential treatments. Understanding the capacity and safety of interventions to prevent or mitigate the effects of fetal programming is paramount.
We cordially invite submissions of your latest research or review articles to this Special Issue, aimed at elucidating the role of oxidative stress in the developmental origins of disease and exploring the potential therapeutic applications of antioxidants for prevention or treatment.
Dr. Silvia M. Arribas
Dr. David Ramiro-Cortijo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- pregnancy
- germline damage
- obstetric complications
- fetal programming
