Hepato-Pancreato-Biliary Cancers: Pathogenesis, Comorbidities and Therapy Updated
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 21
Special Issue Editors
Interests: gastrointestinal/biliary diseases; metabolic diseases; congenital heart disease; mitochondrial DNA-related cardiomyopathies; carcinogenesis (bone/liver)
Special Issues, Collections and Topics in MDPI journals
Interests: HIV; tuberculosis; pediatric infectious disease; microbiota in surgery patients
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pathogeneses of hepatopancreatic cancer and cholangiocellular carcinoma are complex, including the abnormal opening of the pancreatic duct into the bile duct, the ductal plate malformation of the liver, bile stasis, stone formation, chronic inflammation, and liver fluke infection. These factors may affect the functionality of the bile duct mucosa for a long time, triggering carcinogenesis. Inflammation is a common promoting factor that leads to epithelial malignancy. Patients may have complications of biliary infection and suffer from bile duct bleeding and organ failure. Most recently, our group has reported on the biliary microbiome separate to the gut microbiome’s involvement. At present, treatment is mainly in toto surgical resection, combined with radiotherapy and chemotherapy. Organ transplantation is rarely a therapeutic option. For advanced cancers for which we have a limited capacity to accomplish a full resection, biliary drainage surgery is useful. This Special Issue will be devoted to the prompt delivery of reports on new advances in our knowledge with regard to the pathogeneses, comorbidities, and therapies for hepato-pancreato-biliary cancers.
Prof. Dr. Consolato M. Sergi
Dr. Paola Di Carlo
Guest Editors
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Keywords
- liver
- bile
- cancer
- microbiome
- pathogenesis
- MiRNA, jaundice
- disease
- therapy
