Soft Tissue Sarcoma: From Diagnosis to Prognosis

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 396

Special Issue Editor


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Guest Editor

Special Issue Information

Dear Colleagues,

The diagnosis of a mesenchymal malignancy or sarcoma requires an arsenal of medical tools, including X-rays, computed tomography (CT) scans, magnetic resonance imaging (MRI), and positron emission tomography (PET) scans. However, the diagnosis or confirmation of a sarcoma still requires the involvement of one or more pathologists. The number of entities ranging from benign to malignant has increased enormously in the last few decades, and the current IARC/WHO classification lists dozens of categories. Recognized for their exceptional service to patients, hospitals, health insurance behemoths, and major corporations, the consultant histopathologists and databases of the Children’s Oncology Group (COG) and the International Society of Pediatric Oncology (SIOP) stand at the forefront of the advancements of pediatric and adult oncology. They pinpoint morphological aspects that have helped molecular biologists identify several pathways that may be targeted for therapy in precision medicine. All physicians involved in diagnosing sarcomas are vital to maintaining operational safety in healthcare and regulatory compliance with significant healthcare agencies. This Special Issue delves into the complexities of soft tissue sarcoma, exploring the journey from diagnosis to prognosis.

Through a compilation of expert insights and cutting-edge research, this Special Issue aims to deepen understanding, discuss best practices, and shed light on the latest advancements in this tumor's diagnosis, treatment, and prognosis. It is an invaluable resource for clinicians, researchers, and patients, fostering a shared commitment to conquer this elusive disease.

Prof. Dr. Consolato M. Sergi
Guest Editor

Manuscript Submission Information

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Keywords

  • soft tissue
  • mesenchyme
  • bone
  • pathogenesis
  • miRNA
  • imaging
  • diagnosis
  • therapy

Published Papers (1 paper)

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Review

11 pages, 1756 KiB  
Review
Giant Myxofibrosarcoma in the Lower Limb: An Overview of Diagnostic and Clinical Management
by Răzvan Ene, Alexandru Lisias Dimitriu, Ileana Peride, Mirela Țigliș, Elisa Georgiana Popescu, Eduard Cătălin Georgescu, Tiberiu Paul Neagu, Ionel Alexandru Checherita and Andrei Niculae
Diagnostics 2024, 14(12), 1298; https://doi.org/10.3390/diagnostics14121298 - 19 Jun 2024
Viewed by 359
Abstract
Myxofibrosarcoma (MFS), an aggressive soft tissue sarcoma, is one of the undifferentiated pleomorphic sarcomas; it has a low incidence, affecting people in the sixth to eighth decades of life. It usually involves the extremities and is painless with a slow-growing pattern. Based on [...] Read more.
Myxofibrosarcoma (MFS), an aggressive soft tissue sarcoma, is one of the undifferentiated pleomorphic sarcomas; it has a low incidence, affecting people in the sixth to eighth decades of life. It usually involves the extremities and is painless with a slow-growing pattern. Based on the case of a 52-year-old female patient who presented with a painful, massive, rapid-growing, ulcerated tumor of the anterior surface of the left thigh, we performed a literature review regarding the current standard of care for patients with MFS. Computed tomography examination, followed by magnetic resonance imaging and surgical biopsy with histopathological examination, confirmed the diagnosis and the presence of lung and inguinal lymph node metastases. Due to the rapid-growing pattern and the local aggressiveness, our tumor board team recommended emergency excisional surgery, with subsequent reconstructive procedures followed by referral to an oncological center. This review emphasizes the importance of proper and rapid diagnosis, followed by multidisciplinary management, for MFS cases with atypical presentation and distal metastases to improve overall outcomes. Full article
(This article belongs to the Special Issue Soft Tissue Sarcoma: From Diagnosis to Prognosis)
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