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Biomedicines
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Editorial Board Members' Collection Series: Cell Biology and Pathology (2nd...
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Editorial Board Members' Collection Series: Cell Biology and Pathology (2nd Edition)

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cell Biology and Pathology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 754

Special Issue Editors

Dr. Georgia Levidou

E-Mail Website
Guest Editor
Department of Pathology, Paracelsus Medical University, 90419 Nuremberg, Germany
Interests: cancer; biomarkers; molecular biology; immunohistochemistry; precision medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Pedro A. José

E-Mail Website
Guest Editor
Medicine and Physiology/Pharmacology, School of Medicine and Health Sciences, The George Washington University, Washington, DC, USA
Interests: hypertension; renal physiology; ion transport; oxidative stress; pharmacogenomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to announce this collection titled “Editorial Board Members’ Collection Series: Cell Biology and Pathology  (2nd Edition)”. This Special Issue will be a collection of papers produced by researchers invited by the Editorial Board Members. The aim is to provide a platform for networking and communication between biomedicines and scholars in the field of cell biology and pathology. All papers will be fully open access upon publication after peer review.

Dr. Georgia Levidou
Dr. Pedro A. José
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular pathology
  • cell biology
  • oxidative stress

Published Papers (1 paper)

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Research

17 pages, 11059 KiB  
Article
The Prognostic Value of Proliferative Activity in Cutaneous Melanoma: A Pilot Study Evaluating the Mitotic Rate and Ki67 Index to Predict Patient Outcomes
by Dana Antonia Tapoi, Ancuța-Augustina Gheorghișan-Gălățeanu, Laura Maria Gosman, Diana Derewicz and Mariana Costache
Biomedicines 2024, 12(6), 1318; https://doi.org/10.3390/biomedicines12061318 - 13 Jun 2024
Viewed by 467
Abstract
Proliferative activity in cutaneous melanomas can be appreciated both histopathologically by counting mitotic figures and immunohistochemically through the Ki67 index, but the prognostic value of each method is still a matter of debate. In this context, we performed a retrospective study on 33 [...] Read more.
Proliferative activity in cutaneous melanomas can be appreciated both histopathologically by counting mitotic figures and immunohistochemically through the Ki67 index, but the prognostic value of each method is still a matter of debate. In this context, we performed a retrospective study on 33 patients diagnosed with cutaneous melanomas between 2013 and 2018 in order to evaluate progression-free survival and overall survival. Multivariate Cox proportional hazards regression was performed by considering both clinical histopathological and immunohistochemical features. The mitotic rate was significantly independently associated with both outcomes, while the Ki67 index was not an independent prognostic factor. However, the Ki67 predictive accuracy could be improved by establishing both a cut-off value and a standardized protocol for evaluating its expression. Until these desiderata are met, the mitotic rate remains superior to the Ki67 index for predicting prognosis in cutaneous melanomas, as also has the advantage of being easily interpreted in a standard histopathological examination regardless of the pathologist’s experience and with no further financial expenses. Importantly, this is one of very few articles that has shown perineural invasion to be an independent prognostic factor for both progression-free survival and overall survival in cutaneous melanomas. As a consequence, this parameter should become a mandatory feature in the histopathological evaluation of cutaneous melanomas as it can improve the identification of patients who are at high risk for disease progression. Full article
(This article belongs to the Special Issue Editorial Board Members' Collection Series: Cell Biology and Pathology (2nd Edition))
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