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Brain Sciences
Special Issues
Recent Advances in Hearing Impairment
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Recent Advances in Hearing Impairment

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuro-otology and Neuro-ophthalmology".

Deadline for manuscript submissions: 1 August 2024 | Viewed by 2256

Special Issue Editor

Prof. Dr. Agnieszka Szczepek

E-Mail Website
Guest Editor
Department of Otorhinolaryngology, Head and Neck Surgery, Charité Universitätsmedizin, Berlin, Germany
Interests: hearing research; inner ear immunology; ototoxicity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hearing impairment is a common condition that has received increased attention recently. Scientific studies showing a link between untreated hearing loss and the development of dementia have been particularly instrumental in raising the profile of hearing loss. The classic causes of hearing loss or deafness are genetic predisposition, ototoxic substances and drugs, noise, and aging. Some diseases, such as diabetes, multiple sclerosis, autoimmune diseases, or certain cancers, are also affected by the development of hearing loss. Because this field of research is evolving exponentially, a thematic collection of the latest discoveries could help us keep up to date with these developments.

This Special Issue aims to collate recent clinical and basic research that provides new information on the ototoxic effects of drugs (including biologics), as well as the lesser-known disease entities associated with hearing impairment, such as (but not limited to) temporomandibular joint disorders, kidney diseases, Hashimoto's disease, or mitochondrial diseases. New biomarkers for hearing loss are also covered.

Original papers (clinical and basic research), case reports, and review articles are welcome. Opinion papers will also be considered in special cases.

Prof. Dr. Agnieszka Szczepek
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ototoxicity
  • autoimmune disease
  • cochlear synaptopathy
  • hair cell loss
  • spiral ganglion damage
  • translational research
  • audiology
  • animal models
  • biomarkers for hearing loss

Published Papers (3 papers)

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Research

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12 pages, 2433 KiB  
Article
MRI-Based Inner Ear Assessment and Cochlin Tomoprotein-Based Evaluation of Perilymphatic Fistula in Patients with Sudden Hearing Loss
by Rayoung Kim, Denis Mihailovic, Conrad Riemann, Alexander Kilgué, Christoph Joachim Pfeiffer, Hans-Björn Gehl, Lars-Uwe Scholtz and Ingo Todt
Brain Sci. 2024, 14(7), 681; https://doi.org/10.3390/brainsci14070681 (registering DOI) - 5 Jul 2024
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Abstract
Objectives: To study the correlation between positive cochlin tomoprotein testing (CTP), magnetic resonance (MR) imaging, and the auditory and vestibular function amongst patients with sudden hearing loss. Study Design: Prospective case series. Methods: We prospectively examined eight patients who presented with sudden hearing [...] Read more.
Objectives: To study the correlation between positive cochlin tomoprotein testing (CTP), magnetic resonance (MR) imaging, and the auditory and vestibular function amongst patients with sudden hearing loss. Study Design: Prospective case series. Methods: We prospectively examined eight patients who presented with sudden hearing loss (>60 dB) with or without vertigo or tinnitus. We performed an ELISA-based CTP detection test using middle ear lavage samples. In addition to the CTP examination, a magnetic resonance imaging (MRI) examination was performed using different sequences (T1 and a T1 sequence with a contrast medium (CM), a T2 sequence, 4 h delayed intravenous gadolinium-enhanced three-dimensional fluid-attenuated inversion recovery (3D FLAIR)). Results: All patients with sudden hearing loss (>60 dB) presented a non-specific contrast enhancement in the cochlea and vestibulum on the affected side on delayed 3D-FLAIR MRI. Four patients had a positive CTP test, suggesting a perilymphatic fistula (PLF). However, no specific MRI signal for a PLF was observed. Conclusions: Using multimodal diagnostic measures, such as CTP testing and different MRI sequences, no correlation could be found in patients with a PLF. Full article
(This article belongs to the Special Issue Recent Advances in Hearing Impairment)
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15 pages, 262 KiB  
Article
Wideband Tympanometry and Pressurized Otoacoustic Emissions in Children with Surgical Excision of Palatine and/or Pharyngeal Tonsils
by Aline Buratti Sanches, Milaine Dominici Sanfins, Piotr Henryk Skarzynski, Magdalena Beata Skarżyńska, Henrique Costa Penatti, Caroline Donadon, Ingrid Pereira de Souza, Ingridy Vitoria da Silva and Maria Francisca Colella-Santos
Brain Sci. 2024, 14(6), 598; https://doi.org/10.3390/brainsci14060598 - 14 Jun 2024
Viewed by 431
Abstract
Palatine and pharyngeal tonsil hypertrophy may lead to dysfunction of the auditory tube due to a propensity for infection, potentially giving rise to otitis media. This is a quantitative and longitudinal study, developed from 2019 to 2021, at the State University of Campinas [...] Read more.
Palatine and pharyngeal tonsil hypertrophy may lead to dysfunction of the auditory tube due to a propensity for infection, potentially giving rise to otitis media. This is a quantitative and longitudinal study, developed from 2019 to 2021, at the State University of Campinas (UNICAMP). The studied sample comprised 15 participants aged 5 to 12 years (mean 7.9 years), 12 male and 3 female, arranged into two groups: children diagnosed with pharyngeal and/or palatine tonsil hypertrophy who were candidates for surgery (G1), and children who were later evaluated after surgery (G2). As part of the test, an otoscopy and measurements of logoaudiometry, pure-tone threshold audiometry, wideband tympanometry (ambient and peak pressure), and otoacoustic emissions (TEOAEs and DPOAEs, both at ambient and peak pressure) were all performed. There were statistically significant differences between phases in pure-tone audiometry, in terms of 226 Hz tympanometry, wideband tympanometry in peak pressure conditions, in the amplitude measurement TEOAEs in both pressure conditions, in DPOAEs in ambient pressure conditions, and in the signal/noise measurement in both pressures in DPOAEs. Overall, it was found that hearing tests were different for subjects with palatine and pharyngeal tonsil hypertrophy compared to the post-surgical group. Full article
(This article belongs to the Special Issue Recent Advances in Hearing Impairment)

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12 pages, 1874 KiB  
Hypothesis
Cross-Modal Tinnitus Remediation: A Tentative Theoretical Framework
by Antoine J. Shahin, Mariel G. Gonzales and Andrew Dimitrijevic
Brain Sci. 2024, 14(1), 95; https://doi.org/10.3390/brainsci14010095 - 19 Jan 2024
Viewed by 1252
Abstract
Tinnitus is a prevalent hearing-loss deficit manifested as a phantom (internally generated by the brain) sound that is heard as a high-frequency tone in the majority of afflicted persons. Chronic tinnitus is debilitating, leading to distress, sleep deprivation, anxiety, and even suicidal thoughts. [...] Read more.
Tinnitus is a prevalent hearing-loss deficit manifested as a phantom (internally generated by the brain) sound that is heard as a high-frequency tone in the majority of afflicted persons. Chronic tinnitus is debilitating, leading to distress, sleep deprivation, anxiety, and even suicidal thoughts. It has been theorized that, in the majority of afflicted persons, tinnitus can be attributed to the loss of high-frequency input from the cochlea to the auditory cortex, known as deafferentation. Deafferentation due to hearing loss develops with aging, which progressively causes tonotopic regions coding for the lost high-frequency coding to synchronize, leading to a phantom high-frequency sound sensation. Approaches to tinnitus remediation that demonstrated promise include inhibitory drugs, the use of tinnitus-specific frequency notching to increase lateral inhibition to the deafferented neurons, and multisensory approaches (auditory–motor and audiovisual) that work by coupling multisensory stimulation to the deafferented neural populations. The goal of this review is to put forward a theoretical framework of a multisensory approach to remedy tinnitus. Our theoretical framework posits that due to vision’s modulatory (inhibitory, excitatory) influence on the auditory pathway, a prolonged engagement in audiovisual activity, especially during daily discourse, as opposed to auditory-only activity/discourse, can progressively reorganize deafferented neural populations, resulting in the reduced synchrony of the deafferented neurons and a reduction in tinnitus severity over time. Full article
(This article belongs to the Special Issue Recent Advances in Hearing Impairment)
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