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Cells
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The Role of Nano Vesicles in the Tumor Microenvironment
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The Role of Nano Vesicles in the Tumor Microenvironment

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Microenvironment".

Deadline for manuscript submissions: closed (22 February 2022) | Viewed by 14581

Special Issue Editor

Prof. Dr. Ziv Gil

E-Mail Website
Guest Editor
1. The Laboratory for Applied Cancer Research, Rambam Healthcare Campus, Clinical Research Institute at Rambam, Rappaport Institute of Medicine and Research, The Technion, Israel Institute of Technology, Haifa, Israel
2. Department of Otolaryngology Head and Neck Surgery, The Head and Neck Center, Rambam Healthcare Campus, Clinical Research Institute at Rambam, Rappaport Institute of Medicine and Research, The Technion, Israel Institute of Technology, Haifa, Israel
Interests: tumor microenvironment; nano vesicles; exosomes; tumor associate macrophages; pancreas cancer; head and neck cancer; neural invasion; RET; healthcare management
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few years, it has been established that extracellular vesicles (EVs) can be found in almost all cell types. The EVs’ lipid membrane protects its cargo from enzymatic degradation, making them ideal carriers for local and long-distance transport. Hence, they play a critical role in intercellular communication in physiological and pathological conditions. EVs serve as transport vehicles for lipids, proteins, and nucleic acids and are involved in managing tumor development and chemotherapy resistance and in the tumor microenvironment (TME).

Therefore, improving knowledge on EVs has improved our understanding of cancer biology as far as tumor development, growth, metastasis, and chemoresistance are concerned and can give rise to new treatment options.

This Special Issue aims to explore EVs’ potential as the next generation of diagnosis and therapy in the field of tumors and the tumor microenvironment and suggest possible future directions of research in this field. Focusing on technological advances in EV purification and characterization will help to improve EV detection and cargo evaluation in the clinical setting.

We look forward to your contributions.

Prof. Dr. Ziv Gil
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles
  • tumor microenvironment
  • exosomes
  • drug resistance

Published Papers (3 papers)

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Review

21 pages, 1603 KiB  
Review
The Role of Extracellular Vesicles in Metabolic Reprogramming of the Tumor Microenvironment
by Eran S. Fridman, Lana Ginini and Ziv Gil
Cells 2022, 11(9), 1433; https://doi.org/10.3390/cells11091433 - 23 Apr 2022
Cited by 19 | Viewed by 3573
Abstract
The tumor microenvironment (TME) includes a network of cancerous and non-cancerous cells, together with associated blood vessels, the extracellular matrix, and signaling molecules. The TME contributes to cancer progression during various phases of tumorigenesis, and interactions that take place within the TME have [...] Read more.
The tumor microenvironment (TME) includes a network of cancerous and non-cancerous cells, together with associated blood vessels, the extracellular matrix, and signaling molecules. The TME contributes to cancer progression during various phases of tumorigenesis, and interactions that take place within the TME have become targets of focus in cancer therapy development. Extracellular vesicles (EVs) are known to be conveyors of genetic material, proteins, and lipids within the TME. One of the hallmarks of cancer is its ability to reprogram metabolism to sustain cell growth and proliferation in a stringent environment. In this review, we provide an overview of TME EV involvement in the metabolic reprogramming of cancer and stromal cells, which favors cancer progression by enhancing angiogenesis, proliferation, metastasis, treatment resistance, and immunoevasion. Targeting the communication mechanisms and systems utilized by TME-EVs is opening a new frontier in cancer therapy. Full article
(This article belongs to the Special Issue The Role of Nano Vesicles in the Tumor Microenvironment)
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30 pages, 740 KiB  
Review
Insight into Extracellular Vesicle-Cell Communication: From Cell Recognition to Intracellular Fate
by Lana Ginini, Salem Billan, Eran Fridman and Ziv Gil
Cells 2022, 11(9), 1375; https://doi.org/10.3390/cells11091375 - 19 Apr 2022
Cited by 55 | Viewed by 6426
Abstract
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and exosomes, and carry a range of nucleic acids and proteins that are necessary for cell-to-cell communication via interaction on the cells surface. They [...] Read more.
Extracellular vesicles (EVs) are heterogamous lipid bilayer-enclosed membranous structures secreted by cells. They are comprised of apoptotic bodies, microvesicles, and exosomes, and carry a range of nucleic acids and proteins that are necessary for cell-to-cell communication via interaction on the cells surface. They initiate intracellular signaling pathways or the transference of cargo molecules, which elicit pleiotropic responses in recipient cells in physiological processes, as well as pathological processes, such as cancer. It is therefore important to understand the molecular means by which EVs are taken up into cells. Accordingly, this review summarizes the underlying mechanisms involved in EV targeting and uptake. The primary method of entry by EVs appears to be endocytosis, where clathrin-mediated, caveolae-dependent, macropinocytotic, phagocytotic, and lipid raft-mediated uptake have been variously described as being prevalent. EV uptake mechanisms may depend on proteins and lipids found on the surfaces of both vesicles and target cells. As EVs have been shown to contribute to cancer growth and progression, further exploration and targeting of the gateways utilized by EVs to internalize into tumor cells may assist in the prevention or deceleration of cancer pathogenesis. Full article
(This article belongs to the Special Issue The Role of Nano Vesicles in the Tumor Microenvironment)
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26 pages, 2898 KiB  
Review
The Role of Extracellular Vesicles in Cancer–Nerve Crosstalk of the Peripheral Nervous System
by Yuanning Guo and Ziv Gil
Cells 2022, 11(8), 1294; https://doi.org/10.3390/cells11081294 - 11 Apr 2022
Cited by 12 | Viewed by 4004
Abstract
Although the pathogenic operations of cancer–nerve crosstalk (e.g., neuritogenesis, neoneurogensis, and perineural invasion—PNI) in the peripheral nervous system (PNS) during tumorigenesis, as well as the progression of all cancer types is continuing to emerge as an area of unique scientific interest and study, [...] Read more.
Although the pathogenic operations of cancer–nerve crosstalk (e.g., neuritogenesis, neoneurogensis, and perineural invasion—PNI) in the peripheral nervous system (PNS) during tumorigenesis, as well as the progression of all cancer types is continuing to emerge as an area of unique scientific interest and study, extensive, wide-ranging, and multidisciplinary investigations still remain fragmented and unsystematic. This is especially so in regard to the roles played by extracellular vesicles (EVs), which are lipid bilayer-enclosed nano- to microsized particles that carry multiple-function molecular cargos, facilitate intercellular communication in diverse processes. Accordingly, the biological significance of EVs has been greatly elevated in recent years, as there is strong evidence that they could contribute to important and possibly groundbreaking diagnostic and therapeutic innovations. This can be achieved and the pace of discoveries accelerated through cross-pollination from existing knowledge and studies regarding nervous system physiology and pathology, as well as thoroughgoing collaborations between oncologists, neurobiologists, pathologists, clinicians, and researchers. This article offers an overview of current and recent past investigations on the roles of EVs in cancer–nerve crosstalk, as well as in neural development, physiology, inflammation, injury, and regeneration in the PNS. By highlighting the mechanisms involved in physiological and noncancerous pathological cellular crosstalk, we provide hints that may inspire additional translational studies on cancer–nerve interplay. Full article
(This article belongs to the Special Issue The Role of Nano Vesicles in the Tumor Microenvironment)
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