Measurements and Standards for Cancer Biomarkers in Clinical Testing

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Laboratory Medicine".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2468

Special Issue Editor

National Institute of Standards and Technology, Gaithersburg, MD, USA
Interests: cancer biomarker; standards development; assay standardization; liquid biopsy; regenerative medicine

Special Issue Information

Dear Colleagues, 

Cancer biomarkers have been used to guide clinical decision-making, including risk assessment, screening, diagnosis, treatment selection, the determination of prognosis, the prediction of response to a therapy, and monitoring response and outcomes. Therefore, the accuracy, reliability, and comparability of cancer biomarker measurements is critical and essential if results are to be optimally interpreted for patient care. Standards and reference materials are well-characterized samples that are ensured to be homogenous and stable and accurately reflect the intended analyte. They can be used to ensure that measurement methods are working correctly, to calibrate instruments, to evaluate assay performance, to identify the weaknesses of the measurement process, and to assign values to other materials. Standards and reference materials for cancer biomarkers are highly desired to improve the confidence and reliability of cancer biomarker clinical testing.

This goal of this Special Issue is to present research articles, technical briefs, and scholarly and critical reviews on the topic reflected in the title, “Measurements and Standards for Cancer Biomarkers in Clinical Testing”. We are gathering contributions covering all aspects related to these efforts, including pre-analytical and analytical controls, standards, and reference material development for cancer biomarkers testing. Even though cancer is a disease of the genome, contributions may be related, but not limited, to DNA, RNA, proteins, metabolites, and current and prospective cancer biomarkers in tissue and liquid biopsy.

Dr. Hua-Jun He
Guest Editor

Manuscript Submission Information

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Keywords

  • cancer biomarkers
  • measurements
  • standards
  • reference materials
  • standardization
  • clinical testing

Published Papers (1 paper)

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Research

29 pages, 10037 KiB  
Article
Key Members of the CmPn as Biomarkers Distinguish Histological and Immune Subtypes of Hepatic Cancers
by Johnathan Abou-Fadel, Victoria Reid, Alexander Le, Jacob Croft and Jun Zhang
Diagnostics 2023, 13(6), 1012; https://doi.org/10.3390/diagnostics13061012 - 7 Mar 2023
Cited by 2 | Viewed by 1823
Abstract
Liver cancer, comprising hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), is a leading cause of cancer-related deaths worldwide. The liver is a primary metabolic organ for progesterone (PRG) and PRG exerts its effects through classic nuclear PRG receptors (nPRs) and non-classic membrane PRG receptors [...] Read more.
Liver cancer, comprising hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), is a leading cause of cancer-related deaths worldwide. The liver is a primary metabolic organ for progesterone (PRG) and PRG exerts its effects through classic nuclear PRG receptors (nPRs) and non-classic membrane PRG receptors (mPRs) or a combination of both. Previous studies have shown that the CCM signaling complex (CSC) couples both nPRs and mPRs to form the CmPn (CSC-mPR-PRG-nPR) signaling network, which is involved in multiple cellular signaling pathways, including tumorigenesis of various cancers. Despite advances in treatment, 5-year survival rates for liver cancer patients remain low, largely due to the chemoresistant nature of HCCs. The lack of sensitive and specific biomarkers for liver cancer diagnosis and prognosis emphasizes the need for identifying new potential biomarkers. We propose the potential use of CmPn members’ expression data as prognostic biomarkers or biomarker signatures for the major types of hepatic cancer, including HCCs and CCAs, as well as rare subtypes such as undifferentiated pleomorphic sarcoma (UPS) and hepatic angiosarcoma (HAS). In this study, we investigated the CmPn network through RNAseq data and immunofluorescence techniques to measure alterations to key cancer pathways during liver tumorigenesis. Our findings reveal significant differential expression of multiple CmPn members, including CCM1, PAQR7, PGRMC1, and nPRs, in both HCCs and CCAs, highlighting the crucial roles of mPRs, nPRs, and CSC signaling during liver tumorigenesis. These key members of the CmPn network may serve as potential biomarkers for the diagnosis and prognosis of liver cancer subtypes, including rare subtypes. Full article
(This article belongs to the Special Issue Measurements and Standards for Cancer Biomarkers in Clinical Testing)
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