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Neuroglial Cross-Talk in Neuroprotection and Plasticity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 3161

Special Issue Editors


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Guest Editor
Department of Biomedical and Biotechnological Sciences (BIOMETC), Section of Physiology, University of Catania, Via S. Sofia 89, 95123 Catania, Italy
Interests: physiology; morphology; molecular pathology
Special Issues, Collections and Topics in MDPI journals

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Co-Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
Interests: compensatory changes; reactive gliosis; connexin; neuroinflammation; neurodegeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Although progressive neuronal dysfunction represents a common hallmark of neurodegenerative disorders, the heterogeneity of the underlying cellular and molecular mechanisms limits the opportunities to restore or slow down disease progression.

Plastic changes in the surviving cell populations may produce functional restoration, and exploiting compensatory changes occurring in disease may represent a crucial factor in degenerative diseases.

Many authors suggest neurodegeneration as the completion of a multisystem disease caused by a network failure instead of a cell-autonomous process and disease onset and progression.

Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new targets for neurodegenerative disorders. Particularly, astroglial and microglial phenotypes and interactions, such as connexin-based exchanges, may either support or worsen potential regenerative and/or compensatory processes.

This Special Issue, “Neuroglial Cross-Talk in Neuroprotection and Plasticity”, aims to collect original research manuscripts, short communications and reviews on latest progresses uncovering mechanisms and strategies for neurodegenerative diseases.

Prof. Rosalba Parenti
Dr. Nunzio Vicario
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • neurodegeneration
  • regeneration
  • plasticity
  • compensatory changes
  • reactive gliosis
  • extracellular signaling
  • intercellular communication
  • connexin
  • imaging
  • animal model

Published Papers (1 paper)

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Review

18 pages, 12583 KiB  
Review
Therapeutic Potential of AAV1-Rheb(S16H) Transduction against Neurodegenerative Diseases
by Youngpyo Nam, Gyeong Joon Moon and Sang Ryong Kim
Int. J. Mol. Sci. 2021, 22(6), 3064; https://doi.org/10.3390/ijms22063064 - 17 Mar 2021
Cited by 2 | Viewed by 2752
Abstract
Neurotrophic factors (NTFs) are essential for cell growth, survival, synaptic plasticity, and maintenance of specific neuronal population in the central nervous system. Multiple studies have demonstrated that alterations in the levels and activities of NTFs are related to the pathology and symptoms of [...] Read more.
Neurotrophic factors (NTFs) are essential for cell growth, survival, synaptic plasticity, and maintenance of specific neuronal population in the central nervous system. Multiple studies have demonstrated that alterations in the levels and activities of NTFs are related to the pathology and symptoms of neurodegenerative disorders, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and Huntington’s disease. Hence, the key molecule that can regulate the expression of NTFs is an important target for gene therapy coupling adeno-associated virus vector (AAV) gene. We have previously reported that the Ras homolog protein enriched in brain (Rheb)–mammalian target of rapamycin complex 1 (mTORC1) axis plays a vital role in preventing neuronal death in the brain of AD and PD patients. AAV transduction using a constitutively active form of Rheb exerts a neuroprotective effect through the upregulation of NTFs, thereby promoting the neurotrophic interaction between astrocytes and neurons in AD conditions. These findings suggest the role of Rheb as an important regulator of the regulatory system of NTFs to treat neurodegenerative diseases. In this review, we present an overview of the role of Rheb in neurodegenerative diseases and summarize the therapeutic potential of AAV serotype 1 (AAV1)-Rheb(S16H) transduction in the treatment of neurodegenerative disorders, focusing on diseases, such as AD and PD. Full article
(This article belongs to the Special Issue Neuroglial Cross-Talk in Neuroprotection and Plasticity)
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