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Non-motor Symptoms in Movement Disorders
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Non-motor Symptoms in Movement Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 633

Special Issue Editors

Prof. Dr. Francesca Morgante

E-Mail Website
Guest Editor
Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London SW17 0RE, UK
Interests: Parkinson’s disease; dystonia; tremor; deep brain stimulation; device-aided therapies; rare movement disorders
Dr. Lucia Ricciardi

E-Mail Website
Guest Editor
Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George’s University of London, London SW17 0RE, UK
Interests: cognitive, psychiatric and emotional dysfunction in patients with movement disorders, especially those with Parkinson’s disease

Special Issue Information

Dear Colleagues,

People with movement disorders present a plethora of non-motor symptoms (NMS), which are very disabling and impact patients’ and their families’ quality of life.

The research on NMS in people with Parkinson’s disease has enormously expanded in the last decade, underlining the importance of the proper diagnosis of these symptoms and the need for multidisciplinary management. Less is known about this topic in patients with atypical Parkinsonian disorders, with dystonia and with tremor, although NMS such as anxiety, depression, excessive daytime sleepiness, cognitive disturbances, and poor sleep are commonly associated with these disorders.

Finally, Huntington’s disease and tic disorders have core features of NMS, especially in the neuropsychiatric and cognitive domains. Recently, functional movement disorders have gained great attention from clinicians and researchers, and in these patients, pain, fatigue, cognitive complaints and psychiatric comorbidities have a detrimental impact on quality of life.

There are several knowledge gaps to be addressed regarding the pathological basis, diagnosis and management of NMS in movement disorders. This topic requires dedicated knowledge and multidisciplinary management. For all these reasons, it seemed necessary to create a Special Issue on this topic. With this Special Issue, we hope to encourage submissions that discuss the current state of the art, address ongoing knowledge gaps, and focus on ongoing controversies and management related to NMS in movement disorders.

Prof. Dr. Francesca Morgante
Dr. Lucia Ricciardi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • movement disorders
  • Parkinson’s disease
  • dystonia
  • tremor
  • non-motor symptoms
  • sleep
  • neuropsychiatric symptoms

Published Papers (2 papers)

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Research

11 pages, 811 KiB  
Article
The Effects of Multidisciplinary Intensive Rehabilitation on Cognitive and Executive Functions in Parkinson’s Disease: A Clinical Database Analysis
by Ivana Baldassarre, Rossella Rotondo, Laura Piccardi, Lorenza Leonardi, Danilo Lanni, Maria Gaglione, Fabrizio Stocchi, Massimo Fini, Michela Goffredo, Elvira Padua and Maria Francesca De Pandis
J. Clin. Med. 2024, 13(13), 3884; https://doi.org/10.3390/jcm13133884 - 2 Jul 2024
Viewed by 189
Abstract
Background/Objectives: This study is based on data collected from a medical health record review to assess whether multidisciplinary intensive rehabilitation treatment in Parkinson’s disease (PD) patients can improve global cognitive functioning and executive functions. Methods: The data related to PD patients were [...] Read more.
Background/Objectives: This study is based on data collected from a medical health record review to assess whether multidisciplinary intensive rehabilitation treatment in Parkinson’s disease (PD) patients can improve global cognitive functioning and executive functions. Methods: The data related to PD patients were extrapolated from a clinical database called “NeuroRehab”. A total of 104 PD patients (51 males; 53 females) performed 6 weeks of multidisciplinary intensive rehabilitation treatment in clinical practice from January 2019 to May 2023. This training program was characterized by three daily sessions of 60 min of activities (muscle relaxation and stretching exercises, moderate physical aerobic exercise, and occupational therapy). The patients were classified and stratified according to disease severity (according to the Hoehn and Yahr scale), postural instability and gait difficulty (PIGD) or tremor-dominant (TD) subtypes, disease duration (DD), and the presence of dyskinesias. The effect of multidisciplinary intensive rehabilitation treatment on cognitive and executive functions was evaluated through the administration of cognitive tests, such as the Mini–Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Frontal Assessment Battery (FAB). All the parameters were evaluated at the baseline (T0) and at the end of the rehabilitation program (T1). Results: The multidisciplinary intensive rehabilitation treatment significantly improved cognitive performance. The MMSE, MoCA, and FAB test scores after the rehabilitation program (T1) were significantly higher compared to the scores obtained at the baseline (T0). Moreover, further analyses on subgroups of the patients who scored below the cut-off in the MMSE showed that at least 50% of patients overcame the cut-off score. Interestingly, the same analyses performed for the MoCA and FAB revealed a higher rate of improvement in cognitive functions, with normal scores in both tests after 6 weeks of multidisciplinary intensive rehabilitation treatment. Conclusions: This study revealed the potential effects of a 6-week multidisciplinary rehabilitation program in improving cognitive status in a PD inpatient cohort. Full article
(This article belongs to the Special Issue Non-motor Symptoms in Movement Disorders)
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11 pages, 391 KiB  
Article
Non-Motor Symptoms in Primary Familial Brain Calcification
by Giulia Bonato, Paola Cimino, Francesca Pistonesi, Leonardo Salviati, Cinzia Bertolin and Miryam Carecchio
J. Clin. Med. 2024, 13(13), 3873; https://doi.org/10.3390/jcm13133873 - 30 Jun 2024
Viewed by 189
Abstract
Background/Objectives: Primary Familial Brain Calcification is a rare neurodegenerative disorder of adulthood characterized by calcium deposition in the basal ganglia and other brain areas; the main clinical manifestations include movement disorders, mainly parkinsonism. Non-motor symptoms are not well defined in PFBC. This work [...] Read more.
Background/Objectives: Primary Familial Brain Calcification is a rare neurodegenerative disorder of adulthood characterized by calcium deposition in the basal ganglia and other brain areas; the main clinical manifestations include movement disorders, mainly parkinsonism. Non-motor symptoms are not well defined in PFBC. This work aims at defining the burden of non-motor symptoms in PFBC. Methods: A clinical, genetic and neuropsychological evaluation of a cohort of PFBC patients, COMPASS-31 scale administration. Results: A total of 50 PFBC patients were recruited; in 25, the genetic test was negative; 10 carried mutations in SLC20A2 gene, 8 in MYORG, 3 in PDGFB, 1 in PDGFRB, 2 in JAM2 (single mutations), and one test is still ongoing. The main motor manifestation was parkinsonism. Headache was reported in 26% of subjects (especially in PDGFB mutation carriers), anxiety or depression in 62%, psychosis or hallucinations in 10–12%, sleep disturbances in 34%; 14% of patients reported hyposmia, 32% constipation, and 34% urinary disturbances. A neuropsychological assessment revealed cognitive involvement in 56% (sparing memory functions, to some extent). The COMPASS-31 mean score was 20.6, with higher sub-scores in orthostatic intolerance and gastrointestinal problems. MYORG patients and subjects with cognitive decline tended to have higher scores and bladder involvement compared to other groups. Conclusions: The presence of non-motor symptoms is frequent in PFBC and should be systematically assessed to better meet patients’ needs. Full article
(This article belongs to the Special Issue Non-motor Symptoms in Movement Disorders)
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