Zika Virus Infection and Immune Response

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology and Immunology".

Deadline for manuscript submissions: 15 October 2024 | Viewed by 769

Special Issue Editors


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Guest Editor
Trudeau Institute, Saranac Lake, NY 12983, USA
Interests: viral pathogenesis; vertical transmission; virus–host interaction; host immunity

E-Mail Website
Guest Editor
Trudeau Institute, Saranac Lake, NY 12983, USA
Interests: molecular virology; virus-host interaction; flaviviruses; enteroviruses; host immunity

Special Issue Information

Dear Colleagues, 

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus that can cause serious illness, including congenital birth defects and Guillain–Barré syndrome during pregnancy. Up until now, there are no licensed effective vaccines or curative antiviral drugs available to treat Zika virus in humans. In immunocompetent adults, Zika virus causes subclinical manifestations with mild symptoms that usually resolve rapidly. However, infections during pregnancy can have devastating effects on the fetus, particularly microcephaly, craniofacial abnormalities, muscle and joint developmental defects, fetal death, and audiovisual abnormalities. 

For this Special Issue, we welcome research on the latest findings on ZIKV infection, including, but not limited to the following areas:

  • sexual transmission;
  • innate immunity in skin and reproductive organs;
  • molecular pathways impacting ZIKV replication and interferon responses;
  • Zika virus infection in pregnancy, virus transmission across the placental and blood–brain barrier, and host immunity during pregnancy, especially at the maternal–fetal interface;
  • interactions between the virus and brain cells;
  • cross-reactive immunity and antibody-mediated enhancement of infection;
  • therapeutic and prophylactic interventions of viral infection;
  • interventions of disease progression;
  • vaccination during pregnancy. 

The aim of this Special issue is to provide a broad overview of current research on ZIKV and the host immune response from molecular to cellular features, which will help to develop better control of viral infection and clinical interventions. 

As Guest Editors of the Special Issue, we cordially invite you to participate. We encourage authors to submit original research articles, review articles, and short communications related to the topic.

Dr. In-Jeong Kim
Dr. Shelton Bradrick
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Zika virus
  • virus transmission
  • immunopathogenesis
  • innate and adaptive immunity
  • cross-reactive immunity
  • cross-reactivity
  • pregnancy
  • neurodevelopment
  • vaccine
  • antivirals
 

Published Papers (1 paper)

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Research

14 pages, 957 KiB  
Article
Predicting Efficacy of a Purified Inactivated Zika Virus Vaccine in Flavivirus-Naïve Humans Using an Immunological Correlate of Protection in Non-Human Primates
by Camilo J. Acosta, Francesco Nordio, David A. Boltz, Whitney R. Baldwin, Greg Hather and Eloi Kpamegan
Microorganisms 2024, 12(6), 1177; https://doi.org/10.3390/microorganisms12061177 - 11 Jun 2024
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Abstract
A traditional phase 3 clinical efficacy study for a Zika vaccine may be unfeasible because of the current low transmission of Zika virus (ZIKV). An alternative clinical development approach to evaluate Zika vaccine efficacy (VE) is therefore required, delineated in the US FDA’s [...] Read more.
A traditional phase 3 clinical efficacy study for a Zika vaccine may be unfeasible because of the current low transmission of Zika virus (ZIKV). An alternative clinical development approach to evaluate Zika vaccine efficacy (VE) is therefore required, delineated in the US FDA’s Accelerated Approval Program for licensure, which utilizes an anti-Zika neutralizing antibody (Zika NAb) titer correlated with non-human primate (NHP) protection as a surrogate endpoint. In this accelerated approval approach, the estimation of VE would be inferred from the percentage of phase 3 trial participants achieving the established surrogate endpoint. We provide a statistical framework to predict the probability of protection for human participants vaccinated with a purified inactivated ZIKV vaccine (TAK-426), in the absence of VE measurements, using NHP data under a single-correlate model. Based on a logistic regression (LR) with bias-reduction model, a probability of 90% protection in humans is expected with a ZIKV NAb geometric mean titer (GMT) ≥ 3.38 log10 half-maximal effective concentration (EC50). The predicted probability of protection of TAK-426 against ZIKV infection was determined using the two-parameter LR model that fit the calculated VE in rhesus macaques and the flavivirus-naïve phase 1 trial participants’ ZIKV NAb GMTs log10 EC50, measured by a ZIKV reporter virus particle assay, at 1 month post dose 2. The TAK-426 10 µg dose predicted a probability of protection from infection of 98% among flavivirus-naïve phase 1 trial participants. Full article
(This article belongs to the Special Issue Zika Virus Infection and Immune Response)
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