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Microorganisms
Special Issues
Gut Microbiota and Foreign Substances: Drugs, Mycotoxins and Heavy Metals...
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Gut Microbiota and Foreign Substances: Drugs, Mycotoxins and Heavy Metals in Foods

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Gut Microbiota".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 502

Special Issue Editors

Prof. Dr. Ravi Gooneratne

E-Mail Website
Guest Editor
Department of Wine, Food and Molecular Biosciences, Lincoln University, Lincoln, Canterbury 7647, New Zealand
Interests: food toxicology; gut microbiota; food foreign substances; xenobiotics; food mycotoxin; heavy metals; probiotics; pathogenic microorganisms; intestinal inflammation
Special Issues, Collections and Topics in MDPI journals
Dr. Zhijia Fang

E-Mail Website
Guest Editor
Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Provincial Engineering Technology, Research Center of Marine Food, Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China
Interests: obesity genes; heavy metals; cadmium; microbial removal; stress regulation; yeast; gene regulation; fatty acids

Special Issue Information

Dear Colleagues,

An increasing number of foreign substances have been detected owing to an increase in drug usage and the prevalence of food contamination. Concerns regarding their detrimental impacts on human health have grown in recent years. A healthy gut microbiome is a key determinant of host health. The gut microbiome is an easy target for many foreign substances in food, including drugs, mycotoxins and heavy metals. These harmful substances can affect the diversity and abundance of the gut microbiome and cause significant changes in its multiple functions. Therefore, it is of great interest to report the latest research on the mechanisms of foreign substances and their effects on host health from the perspective of the gut microbiota. This Special Issue focuses on the basic concepts and the relevant research methods of various toxic substances, such as drugs, mycotoxins and heavy metals in food, and their toxic effects on the gut microbiome.

Prof. Dr. Ravi Gooneratne
Dr. Zhijia Fang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gut microbiota
  • foreign substances in food
  • xenobiotics
  • food mycotoxins
  • heavy metals
  • probiotics
  • pathogenic microorganisms
  • intestinal inflammation

Published Papers (1 paper)

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Research

11 pages, 2482 KiB  
Article
Fried Soybean Oil Causes Systemic Low-Grade Inflammation by Disrupting the Balance of Gut Microbiota in Mice
by Lianhua Hu, Ling Huang, Zhijia Fang, Chen Wang, **** Luo, Qi Deng, Defeng Xu, Lijun Sun and Ravi Gooneratne
Microorganisms 2024, 12(6), 1210; https://doi.org/10.3390/microorganisms12061210 - 16 Jun 2024
Viewed by 395
Abstract
Previous reports have mainly investigated the long-term effects (>30 d), such as gut microbiota dysbiosis and systemic low-grade inflammation, in mice fed fried oil. However, short-term intake of deep-fried oil is more likely to occur in daily life, and such studies are lacking. [...] Read more.
Previous reports have mainly investigated the long-term effects (>30 d), such as gut microbiota dysbiosis and systemic low-grade inflammation, in mice fed fried oil. However, short-term intake of deep-fried oil is more likely to occur in daily life, and such studies are lacking. This study aimed to investigate the short-term effects of fried oil intake on systemic low-grade inflammation. Male Kunming mice were fed non-fried soybean oil or low (25%), medium (50%), or high (100%)—fried oil at 4.4 g/kg for 6 d. Serum and fecal samples were collected on day 7. In all groups fed fried oil, the serum levels of tumor necrosis factor (TNF-α) were significantly elevated 2-4-fold. Among the gut microbiota, the abundance of Alloprevotella significantly decreased by up to 76%, while Lactobacilli significantly increased by up to 385%. The fecal valeric acid content was significantly increased and positively correlated with TNF-α levels. Both valeric acid and TNF-α levels were positively correlated with the abundance of Lactobacilli and negatively correlated with that of Alloprevotella. In summary, a short-term ingestion of even low doses of fried oil alters the gut microbiota Alloprevotella and Lactobacilli and increases fecal valeric acid content, which correlates with increased serum TNF-α levels. Full article
(This article belongs to the Special Issue Gut Microbiota and Foreign Substances: Drugs, Mycotoxins and Heavy Metals in Foods)
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