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Journals
Microorganisms
Special Issues
Research on Microbial Periprosthetic Infections
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Research on Microbial Periprosthetic Infections

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 270

Special Issue Editors

Dr. Hesham Abdelbary

E-Mail Website
Guest Editor
Department of Surgery, Division of Orthopaedics, The Ottawa Hospital, Ottawa, ON, Canada
Interests: phage; periprosthetic infections
Special Issues, Collections and Topics in MDPI journals
Dr. George Grammatopoulos

E-Mail Website
Guest Editor
Ottawa Hospital, Ottawa, ON, Canada
Interests: orthopedic surgery; hip and knee replacement
Dr. Simon Garceau

E-Mail Website
Guest Editor
Department of Surgery, University of Ottawa, Ottawa, ON, Canada
Interests: periprosthetic joint infection; antibiotic

Special Issue Information

Dear Colleagues,

Implantable medical devices have revolutionized the care provided for patients suffering from a diverse spectrum of medical conditions. Unfortunately, a common complication that hampers the intended benefit of any implanted medical device is periprosthetic infection, with biofilm formation on infected implant surfaces being one of the main the main culprits that poses a significant therapeutic challenge for current standard antimicrobial therapies.

The Special Issue aims to present recent research related to periprosthetic infections, with a focus on, among other potential themes, biofilm biology on various implant surfaces, local and systemic host responses to biofilm formation, approaches to treat and prevent biofilm formation, economic and functional implications of periprosthetic infections. Reviews, original research and communications will be welcome.

Dr. Hesham Abdelbary
Dr. George Grammatopoulos
Dr. Simon Garceau
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofilm
  • implant surface
  • immune system
  • delivery mechanisms
  • antibiotic resistance

Published Papers (1 paper)

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Research

11 pages, 486 KiB  
Article
The Impact of Culture Negativity on the Outcomes of Revision Total Knee Arthroplasty for Chronic PJI
by Emily M. Ronan, Garrett Ruff, Itay Ashkenazi, Hayley Raymond, Casey Cardillo, Jordan C. Villa, Ran Schwarzkopf and Vinay K. Aggarwal
Microorganisms 2024, 12(7), 1384; https://doi.org/10.3390/microorganisms12071384 (registering DOI) - 8 Jul 2024
Abstract
Culture-positive (CP) and culture-negative (CN) periprosthetic joint infections (PJI) remain a crucial area of research; however, current studies comparing these infections rely on unstandardized outcome reporting tools. Our study aimed to compare the outcomes of two-stage revision of CP and CN PJI using [...] Read more.
Culture-positive (CP) and culture-negative (CN) periprosthetic joint infections (PJI) remain a crucial area of research; however, current studies comparing these infections rely on unstandardized outcome reporting tools. Our study aimed to compare the outcomes of two-stage revision of CP and CN PJI using the standardized Musculoskeletal Infection Society (MSIS) outcome reporting tool. We retrospectively reviewed 138 patients who were diagnosed with PJI and indicated for two-stage revision total knee arthroplasty (rTKA). The majority of patients in both CP and CN cohorts achieved infection control without the need for reoperation (54.1% and 62.5%, respectively). There was a significant difference in the overall distribution of MSIS outcomes (p = 0.043), with a significantly greater rate of CN patients falling into Tier 1 (infection control without the use of suppressive antibiotics) (52.5% versus 29.6%, p = 0.011). There was also a significant difference in the distribution of septic versus aseptic reoperations after 2nd stage (p = 0.013), with more CP reoperations being septic and more CN reoperations being aseptic. The duration from first to second stage was significantly shorter in the CN cohort (p = 0.002). While overall infection control was similar between cohorts, these data suggest that the outcomes of two-stage rTKA are favorable in cases of CN PJI. Full article
(This article belongs to the Special Issue Research on Microbial Periprosthetic Infections)
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