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Mesoporous Silica and Related Nanomaterials: Synthesis, Characterization and Applications in Drug Delivery Systems and Green Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Materials Chemistry".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 503

Special Issue Editor


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Guest Editor
Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania
Interests: inorganic and hybrid nanomaterials; mesoporous materials; drug delivery systems; encapsulation of phase change materials; composite nanostructures; nanoconfinement
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to publish some of your recent works in this Special Issue dedicated to mesoporous silica and related nanomaterials. I see this as not only a collection of papers, but rather an opportunity to share results that could bring us together and inspire us for future projects. Topics can include any subject related to mesoporous materials, which could be silica or any other kind, from synthesis and properties, to applications, focused on drug delivery systems or green chemistry. Mesoporous materials offers two main unique properties that are exploited in most applications: a high specific surface area and versatility to control the surface chemistry and interface interactions. Therefore, we encourage works that focus on how these properties have been tailored and integrated with other required qualities to achieve a synergism in the development of a new or a better material dedicated to a specific purpose. It is well known that mesoporous silica has gained a huge interest in development of drug delivery systems, and many manuscripts will be expected from this area, but mesoporous materials have also found their way to other important fields such as green chemistry, a hot topic nowadays. You are welcome to discover how varied and interesting these subjects are and are invited to contribute to our Special Issue.

Prof. Dr. Cristian Matei
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mesoporous materials
  • drug delivery
  • encapsulation
  • nanoconfinement
  • adsorption
  • green chemistry
  • catalysts immobilization
  • catalyst recovery
  • pollutant reduction
  • renewable materials

Published Papers (1 paper)

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Research

18 pages, 2255 KiB  
Article
Anti-Inflammatory, Antidiabetic, and Antioxidant Properties of Extracts Prepared from Pinot Noir Grape Marc, Free and Incorporated in Porous Silica-Based Supports
by Mihaela Deaconu, Anil Abduraman, Ana-Maria Brezoiu, Nada K. Sedky, Simona Ioniță, Cristian Matei, Laila Ziko and Daniela Berger
Molecules 2024, 29(13), 3122; https://doi.org/10.3390/molecules29133122 - 30 Jun 2024
Viewed by 446
Abstract
This study presents properties of hydroethanolic extracts prepared from Pinot Noir (PN) grape pomace through conventional, ultrasound-assisted or solvothermal extraction. The components of the extracts were identified by HPLC. The total content of polyphenols, flavonoids, anthocyanins, and condensed tannins, as well as antioxidant [...] Read more.
This study presents properties of hydroethanolic extracts prepared from Pinot Noir (PN) grape pomace through conventional, ultrasound-assisted or solvothermal extraction. The components of the extracts were identified by HPLC. The total content of polyphenols, flavonoids, anthocyanins, and condensed tannins, as well as antioxidant activity and α-glucosidase inhibitory activity of extracts were evaluated using UV-vis spectroscopy. All extracts were rich in phenolic compounds, proving a good radical scavenging activity. The extract obtained by conventional extraction at 80 °C showed the best α-glucosidase inhibitory activity close to that of (-)-epigallocatechin gallate. To improve the chemical stability of polyphenols, the chosen extract was incorporated in porous silica-based supports: amine functionalized silica (MCM-NH2), fucoidan-coated amine functionalized silica (MCM-NH2-Fuc), MCM-41, and diatomite. The PN extract exhibited moderate activity against Gram-positive S. aureus (MIC = 156.25 μg/mL) better than against Gram-negative E. coli (MIC = 312.5 μg/mL). The biocompatibility of PN extract, free and incorporated in MCM-NH2 and MCM-NH2-Fuc, was assessed on RAW 264.7 mouse macrophage cells, and the samples showcased a good cytocompatibility at 10 µg/mL concentration. At this concentration, PN and PN@MCM-NH2-Fuc reduced the inflammation by inhibiting NO production. The anti-inflammatory potential against COX and LOX enzymes of selected samples was evaluated and compared with that of Indomethacin and Zileuton, respectively. The best anti-inflammatory activity was observed when PN extract was loaded on MCM-NH2-Fuc support. Full article
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