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Recent Research on Cross-Coupling Reactions

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2095

Special Issue Editors


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Guest Editor
Division of Wood Chemistry and Pulp Technology, Department of Fiber and Polymer Technology, School of Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Teknikringen 56-58, SE-100 44 Stockholm, Sweden
Interests: mechanochemistry, catalysis; photoredox catalysis; functionalization of C-H bond; C-C and C-Het couplings; medicinal chemistry; heterocycles; element-organic chemistry; fluorine; phosphorus; green chemistry; sustainability
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Molecular Probes and Prodrugs, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznań, Poland
Interests: C-C couplings; catalysis; organoboron chemistry; NMR; inhibitors; Lewis acidity; peptide synthesis; heterocycles

E-Mail Website
Guest Editor
Department of Chemistry, Faculty of Natural Sciences, Matej Bel University, Tajovkého 40, 97401 Banska Bystrica, Slovakia
Interests: C-C and C-Het couplings; phosphorus chemistry; catalysis; heterocycles; fluorine; mechanochemistry; green chemistry; sustainability
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The discovery of cross-coupling reactions was regarded as a milestone in organic chemistry long before the Nobel Prize in Chemistry of 2010 was awarded to Richard F. Heck, Ei-ichi Negishi and Akira Suzuki. The ability to efficiently and selectively create complex organic structures under mild conditions with the help of metal catalysts opened up possibilities that go beyond the formation of biphenyls. The significance of coupling reactions is reflected by the fact that approximately one-fourth of the medicines synthesized nowadays are made with the use of these couplings. Many multi-ton processes for forming agrochemicals are based on cross-coupling. Beyond its biological applications, Suzuki Polycondensation (SPC) is commonly incorporated in the synthesis and functionalization of a myriad of structures, providing research objects for applications such as organic thin-film transistors (OTFTs), organic light-emitting diodes (OLEDs) and organic photovoltaics.

Development in this branch of organic chemistry has not seemed to slow down, with new findings related to additives, leaving groups, catalysts, reaction conditions and nucleophiles being continuously investigated and published. Furthermore, different aspects of cross-coupling reactions are being explored with the use of experimental as well as computational methodologies to elucidate the mechanistic details of observed reactivities. Thus, we see a need to periodically gather all this new knowledge and highlight the most important findings with potential to significantly impact future research on cross-couplings.

This Special Issue aims to present recent progress made in the field of cross-coupling reactions and their adaptations in various contexts. We are pleased to invite expert researchers in the field to publish their latest developments and concepts in this Special Issue in the form of short communications, full-research papers, perspectives and reviews.

Dr. Viktor Iaroshenko
Dr. Michał Jakubczyk
Dr. Satenik Mkrtchyan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • C–C bond formation
  • C–heteroatom bond formation
  • transition-metal catalysis
  • photoredox catalysis
  • electrochemistry
  • cyclisation
  • mechanochemistry
  • homogeneous and heterogenous catalysis
  • supramolecular catalysis
  • DFT Studies
  • enzymatic reactions
  • sustainability

Published Papers (1 paper)

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Research

9 pages, 939 KiB  
Article
Microwave-Assisted Cu-Catalyzed Diaryletherification for Facile Synthesis of Bioactive Prenylated Diresorcinols
by Seoyoung Jo, Bohun Kang and Jong-Wha Jung
Molecules 2023, 28(1), 62; https://doi.org/10.3390/molecules28010062 - 21 Dec 2022
Cited by 2 | Viewed by 1475
Abstract
Prenylated diresorcinols exhibit various bioactivities, including cytotoxic, antibacterial, and antifungal activities. Therefore, establishing facile and efficient synthetic routes for prenylated diresorcinols facilitates their development as chemical probes or drugs with a novel mode of action. In this study, microwave-assisted copper catalysis was explored [...] Read more.
Prenylated diresorcinols exhibit various bioactivities, including cytotoxic, antibacterial, and antifungal activities. Therefore, establishing facile and efficient synthetic routes for prenylated diresorcinols facilitates their development as chemical probes or drugs with a novel mode of action. In this study, microwave-assisted copper catalysis was explored as a cost-effective and environmentally friendly method for the cross-coupling of sterically hindered ortho-prenylated phenols and aryl halides to produce bioactive prenylated diresorcinols, diorcinol I and leotiomycene B. Notable advantages of microwave-assisted catalysis include not only operational simplicity and rapid heating but also shorter reaction times and higher chemical yields. In addition, highly regioselective prenylation of phenol was achieved for the preparation of ortho-prenyl phenol via directed lithiation and subsequent alkylation. This study provides valuable insights for the preparation of other bioactive prenylated diresorcinols. Furthermore, considering that prenylated benzenoids are biosynthetic precursors of various polycyclic natural products, this synthetic route could be expanded to more complex bioactive compounds possessing diaryl ethers. Full article
(This article belongs to the Special Issue Recent Research on Cross-Coupling Reactions)
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