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Molecules
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Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities
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Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 2131

Special Issue Editors

Prof. Dr. Radosław Kowalski

E-Mail Website
Guest Editor
Department of Analysis and Evaluation of Food Quality, University of Life Sciences in Lublin, 8 Skromna Street, 20-704 Lublin, Poland
Interests: analytical chemistry; chromatography; extraction; phytochemistry; food technology; essential oils; aromas; herbal drug development; antioxidants; dietary supplements; special fats technology; quality and food safety; food contaminations
Special Issues, Collections and Topics in MDPI journals
Dr. Tomasz Baj

E-Mail Website
Guest Editor
Department of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, PL-20-093 Lublin, Poland
Interests: natural product chemistry; antioxidants; analytical chemistry; bioactivity; phytochemicals; extraction

Special Issue Information

Dear Colleagues,

“Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities” is dedicated to unlocking the potential of compounds found in nature. This topic delves into efficient methods for extracting these valuable substances from various natural sources, the precise techniques for isolating them, and the comprehensive strategies for characterizing their properties.

Researchers in this field employ a wide array of tools and methodologies to discover, isolate, and understand the diverse compounds present in plants, microbes, marine organisms, and other natural reservoirs. Secondary plant metabolites are of particular interest. These compounds often possess bioactive properties, making them invaluable for applications in medicine, agriculture, and industry.

The study of natural products extends to examining their chemical structures, assessing biological activities (including antimicrobial, antioxidant, and anticancer properties), elucidating their modes of action, and assessing their potential for drug development, functional foods, and sustainable materials. Moreover, the topic explores sustainable practices that align with environmental conservation and the responsible utilization of nature's wealth.

As an interdisciplinary topic, “Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities” bridges chemistry, biology, pharmacology, and environmental science, fostering collaboration among experts from various domains. It also underscores the importance of preserving biodiversity and exploring new frontiers in natural product research.

Prof. Dr. Radosław Kowalski
Dr. Tomasz Baj
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • secondary metabolites
  • analytical techniques application
  • extraction and separation
  • chemical composition
  • phytochemistry
  • isolation and structure elucidation
  • secondary metabolites
  • antimicrobial activity
  • antioxidant activity
  • anticancer activity

Published Papers (3 papers)

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Research

10 pages, 1264 KiB  
Article
Dentifragilones A–B and Other Benzoic Acid Derivatives from the European Basidiomycete Dentipellis fragilis
by Winnie Chemutai Sum, Sherif S. Ebada, Mahmoud A. A. Ibrahim, Harald Kellner and Marc Stadler
Molecules 2024, 29(12), 2859; https://doi.org/10.3390/molecules29122859 - 16 Jun 2024
Viewed by 610
Abstract
A chemical and biological exploration of the European polypore Dentipellis fragilis afforded two previously undescribed natural products (1 and 2), together with three known derivatives (3–5). Chemical structures of the isolated compounds were confirmed through 1D/2D NMR spectroscopic [...] Read more.
A chemical and biological exploration of the European polypore Dentipellis fragilis afforded two previously undescribed natural products (1 and 2), together with three known derivatives (3–5). Chemical structures of the isolated compounds were confirmed through 1D/2D NMR spectroscopic analyses, mass spectrometry, and by comparison with the reported literature. The relative and absolute configurations of 1 were determined according to the ROESY spectrum and time-dependent density functional theory electronic circular dichroism (TDDFT-ECD), respectively. Furthermore, the absolute configuration of dentipellinol (3) was revisited and revealed to be of (R) configuration. All the isolated compounds were assessed for their cytotoxic and antimicrobial activities, with some being revealed to have weak to moderate antimicrobial activity, particularly against Gram-positive bacteria. Full article
(This article belongs to the Special Issue Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities)
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21 pages, 2593 KiB  
Article
Influence of Major Polyphenols on the Anti-Candida Activity of Eugenia uniflora Leaves: Isolation, LC-ESI-HRMS/MS Characterization and In Vitro Evaluation
by Camylla Janiele Lucas Tenório, Thainá dos Santos Dantas, Lucas Silva Abreu, Magda Rhayanny Assunção Ferreira and Luiz Alberto Lira Soares
Molecules 2024, 29(12), 2761; https://doi.org/10.3390/molecules29122761 - 10 Jun 2024
Viewed by 569
Abstract
The content of chemical constituents in Eugenia uniflora leaf extracts correlates positively with biological activities. The experimental objective was to carry out the phytochemical screening and purification of the major polyphenols from the leaves of E. uniflora. In addition, the anti-Candida [...] Read more.
The content of chemical constituents in Eugenia uniflora leaf extracts correlates positively with biological activities. The experimental objective was to carry out the phytochemical screening and purification of the major polyphenols from the leaves of E. uniflora. In addition, the anti-Candida activity of the hydroalcoholic extract, fraction, subfractions and polyphenols purified were evaluated. After partitioning of the extract with ethyl acetate, the fractions were chromatographed on Sephadex® LH-20 gel followed by RP-flash chromatography and monitored by TLC and RP-HPLC. The samples were characterized by mass spectrometry (LC-ESI-QTOF-MS2) and subjected to the microdilution method in 96-well plates against strains of C. albicans, C. auris, and C. glabrata. Myricitrin (93.89%; w/w; m/z 463.0876), gallic acid (99.9%; w/w; m/z 169.0142), and ellagic acid (94.2%; w/w; m/z 300.9988) were recovered. The polyphenolic fraction (62.67% (w/w) myricitrin) and the ellagic fraction (67.86% (w/w) ellagic acid) showed the best antifungal performance (MIC between 62.50 and 500 μg/mL), suggesting an association between the majority constituents and the antifungal response of E. uniflora derivatives. However, there is a clear dependence on the presence of the complex chemical mixture. In conclusion, chromatographic strategies were effectively employed to recover the major polyphenols from the leaves of the species. Full article
(This article belongs to the Special Issue Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities)
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13 pages, 1938 KiB  
Article
New Pyranone Derivatives and Sesquiterpenoid Isolated from the Endophytic Fungus Xylaria sp. Z184
by Yan Zhang, Yang **, Wensi Yan, Peishan Gu, Ziqian Zeng, Ziying Li, Guangtao Zhang, Mi Wei and Yongbo Xue
Molecules 2024, 29(8), 1728; https://doi.org/10.3390/molecules29081728 - 11 Apr 2024
Viewed by 632
Abstract
The fungus Xylaria sp. Z184, harvested from the leaves of Fallopia convolvulus (L.) Á. Löve, has been isolated for the first time. Chemical investigation on the methanol extract of the culture broth of the titles strain led to the discovery of three new [...] Read more.
The fungus Xylaria sp. Z184, harvested from the leaves of Fallopia convolvulus (L.) Á. Löve, has been isolated for the first time. Chemical investigation on the methanol extract of the culture broth of the titles strain led to the discovery of three new pyranone derivatives, called fallopiaxylaresters A–C (1–3), and a new bisabolane-type sesquiterpenoid, named fallopiaxylarol A (4), along with the first complete set of spectroscopic data for the previously reported pestalotiopyrone M (5). Known pyranone derivatives (6–11), sesquiterpenoids (12–14), isocoumarin derivatives (15–17), and an aromatic allenic ether (18) were also co-isolated in this study. All new structures were elucidated by the interpretation of HRESIMS, 1D, 2D NMR spectroscopy, and quantum chemical computation approach. The in vitro antimicrobial, anti-inflammatory, and α-glucosidase-inhibitory activities of the selected compounds and the crude extract were evaluated. The extract was shown to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells, with an inhibition rate of 77.28 ± 0.82% at a concentration of 50 μg/mL. The compounds 5, 7, and 8 displayed weak antibacterial activity against Staphylococcus areus subsp. aureus at a concentration of 100 μM. Full article
(This article belongs to the Special Issue Secondary Metabolites from Natural Products: Extraction, Isolation and Biological Activities)
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