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Preparation, Characterization, and Effect of Lipid Nanoparticles Used in Different Application Fields IV

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Nanochemistry".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2182

Special Issue Editor

Special Issue Information

Dear Colleagues,

Nanotechnology profoundly impacts our lives in many ways, both positively and negatively. The recent interest in nanoscale products emerged from modern nanotechnology as a multidisciplinary area. Many studies have demonstrated that lipid-based nanoparticles (e.g., nanostructured lipid carriers, solid lipid nanoparticles, nanoemulsions, liposomes, and cubosomes) are largely used to ameliorate the solubility of active principles or to obtain a controlled or target release, creating a modifiable system able to be adapted according to the product requirements. Lipid-based nanoparticles demonstrated their ability to solubilize a number of molecules with different physicochemical properties in well-established, safe, biocompatible and biodegradable matrixes, contributing, as a natural resource, to green nanosystems. When these properties are taken together, lipid-based nanosystems are versatile systems with applications in many fields, including the environmental, veterinary, nutraceutical, cosmetic, biotechnological, biomedical, and pharmaceutical industries. The great level of interest in the various applications of lipid nanoparticles presented in the first three editions of this Special Issue motivated us to propose a fourth installment in this series in order to provide an open forum with the aim of encouraging elaboration upon the research and findings in the field of nanotechnology. Submissions may be in the form of original research or review articles and may focus on a range of issues, such as the production, characterization, structure, and innovative aspects of lipid nanoparticles, possibly presenting new preparation methods, advantages, disadvantages, lipid nanoparticle functionalization, and new applications. Studies with multidisciplinary inputs offering innovative methodologies or insights are also welcome.

Prof. Dr. Rita Cortesi
Guest Editor

Manuscript Submission Information

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Keywords

  • nanocarriers
  • nanotechnology
  • SLN
  • NLC
  • liposomes
  • drug delivery
  • nanomedicine
  • green agriculture

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Published Papers (2 papers)

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Research

19 pages, 854 KiB  
Article
Solid Lipid Nanoparticles Encapsulating a Benzoxanthene Derivative in a Model of the Human Blood–Brain Barrier: Modulation of Angiogenic Parameters and Inflammation in Vascular Endothelial Growth Factor-Stimulated Angiogenesis
by Giuliana Greco, Aleksandra Agafonova, Alessia Cosentino, Nunzio Cardullo, Vera Muccilli, Carmelo Puglia, Carmelina Daniela Anfuso, Maria Grazia Sarpietro and Gabriella Lupo
Molecules 2024, 29(13), 3103; https://doi.org/10.3390/molecules29133103 - 28 Jun 2024
Viewed by 343
Abstract
Lignans, a class of secondary metabolites found in plants, along with their derivatives, exhibit diverse pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory, and antiangiogenic ones. Angiogenesis, the formation of new blood vessels from pre-existing ones, is a crucial process for cancer growth and development. [...] Read more.
Lignans, a class of secondary metabolites found in plants, along with their derivatives, exhibit diverse pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory, and antiangiogenic ones. Angiogenesis, the formation of new blood vessels from pre-existing ones, is a crucial process for cancer growth and development. Several studies have elucidated the synergistic relationship between angiogenesis and inflammation in various inflammatory diseases, highlighting a correlation between inflammation and vascular endothelial growth factor (VEGF)-induced angiogenesis. Thus, the identification of novel molecules capable of modulating VEGF effects presents promising prospects for develo** therapies aimed at stabilizing, reversing, or even arresting disease progression. Lignans often suffer from low aqueous solubility and, for their use, encapsulation in a delivery system is needed. In this research, a bioinspired benzoxantene has been encapsulated in solid lipid nanoparticles that have been characterized for their pharmacotechnical properties and their thermotropic behavior. The effects of these encapsulated nanoparticles on angiogenic parameters and inflammation in VEGF-induced angiogenesis were evaluated using human brain microvascular endothelial cells (HBMECs) as a human blood–brain barrier model. Full article
20 pages, 20959 KiB  
Article
Development of A Nanostructured Lipid Carrier-Based Drug Delivery Strategy for Apigenin: Experimental Design Based on CCD-RSM and Evaluation against NSCLC In Vitro
by **aoxue Wang, **li Liu, Yufei Ma, **nyu Cui, Cong Chen, Guowei Zhu, Yue Sun and Lei Tong
Molecules 2023, 28(18), 6668; https://doi.org/10.3390/molecules28186668 - 17 Sep 2023
Cited by 1 | Viewed by 1397
Abstract
Non-small-cell lung cancer (NSCLC) is the main cause of cancer-related deaths worldwide, with a low five-year survival rate, posing a serious threat to human health. In recent years, the delivery of antitumor drugs using a nanostructured lipid carrier (NLC) has become a subject [...] Read more.
Non-small-cell lung cancer (NSCLC) is the main cause of cancer-related deaths worldwide, with a low five-year survival rate, posing a serious threat to human health. In recent years, the delivery of antitumor drugs using a nanostructured lipid carrier (NLC) has become a subject of research. This study aimed to develop an apigenin (AP)-loaded nanostructured lipid carrier (AP-NLC) by melt sonication using glyceryl monostearate (GMS), glyceryl triacetate, and poloxamer 188. The optimal prescription of AP-NLC was screened by central composite design response surface methodology (CCD-RSM) based on a single-factor experiment using encapsulation efficiency (EE%) and drug loading (DL%) as response values and then evaluated for its antitumor effects on NCI-H1299 cells. A series of characterization analyses of AP-NLC prepared according to the optimal prescription were carried out using transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). Subsequent screening of the lyophilization protectants revealed that mannitol could better maintain the lyophilization effect. The in vitro hemolysis assay of this formulation indicated that it may be safe for intravenous injection. Moreover, AP-NLC presented a greater ability to inhibit the proliferation, migration, and invasion of NCI-H1299 cells compared to AP. Our results suggest that AP-NLC is a safe and effective nano-delivery vehicle that may have beneficial potential in the treatment of NSCLC. Full article
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