Natural Products in Anticancer Therapy
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 602
Special Issue Editor
Interests: cancer chemoprevention; nutrition; olive oil; polyphenols; natural bioactive compounds; antioxidants; oxidative stress; genotoxicity; mutagenicity; apoptosis; cell cycle regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
After cardiovascular diseases, cancer is the second-leading cause of death among non-communicable diseases. Its incidence and mortality are increasing worldwide due to an aging population. Therefore, this disease remains a major public health concern worldwide. Although considerable progress has been made in recent years and several cancer treatment options are now available, their success is often unsatisfactory and accompanied by significant side effects. Indeed, both chemotherapy and small-molecule targeted therapy (SMTT) can cause adverse reactions in normal cells, resulting in undesirable side effects, including nausea, vomiting, diarrhea, rash, fatigue, pain, hypertension, mucositis, alopecia, neuropathy, anemia, emesis, baldness, and myelosuppression. In addition, despite the effectiveness of these drugs in the early phase of the disease, they are often associated with multidrug resistance (MDR), a phenomenon responsible for most of the deaths of cancer patients undergoing treatment. Therefore, further efforts are needed to discover new molecules with better therapeutic properties, higher efficacy, and lower toxicity. Phytochemicals, plant derivatives, or natural products have shown remarkable biological properties capable of interfering with the carcinogenesis process through different molecular mechanisms, including cancer cell proliferation, apoptosis, and differentiation. These effects make it possible to use such natural products as alternative therapeutic or adjuvant treatments with better efficacy and lower toxicity.
This Special Issue aims to identify new plant-derived molecules that are able to prevent and/or suppress the carcinogenesis process at non-toxic doses. Particular emphasis will be given to the results on the bioavailability and anticancer efficacy of natural compounds obtained on animal models of carcinogenesis.
Dr. Roberto Fabiani
Guest Editor
Manuscript Submission Information
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Keywords
- natural products
- bioactive anti‑tumor agents
- phytochemicals
- anticancer plants
- chemotherapy
- targeted therapy
