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Selected Papers from the 1st Aristotle Conference on Chemistry:...
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Selected Papers from the 1st Aristotle Conference on Chemistry: Advances and Challenges in Chemistry

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 1057

Special Issue Editors

Prof. Dr. Thodoris Karapantsios

E-Mail Website
Guest Editor
Department of Chemical Technology, Faculty of Chemistry, Aristotle University of Thessaloniki, University Box 116, 54124 Thessaloniki, Greece
Interests: dynamic multiphase systems; emulsions and foams; wettability of surfaces; rheology and surface tension measurements; water and wastewater; medical diagnostic techniques for blood circulation
Prof. Dr. Victoria Samanidou

E-Mail Website
Guest Editor
Laboratory of Analytical Chemistry, School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: analytical chemistry; sample preparation; chromatography; HPLC; method validation; method development; separation science; food analysis; bioanalysis; environmental analysis; green analytical chemistry; sorptive extraction; microextraction techniques
Special Issues, Collections and Topics in MDPI journals
Dr. Fani Th Mantzouridou

E-Mail Website
Guest Editor
School of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: food chemistry; quality/process control; food biotechnology; fermented foods; bio-based food ingredients; valorization of agro-industrial wastes and residues; in vivo assessment of antioxidant activity; design of experiments
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The 1st Aristotle Conference on Chemistry (ACC) (http://acc2023.chem.auth.gr) will be held from 12 to 15 October 2023 in Thessaloniki, Greece. The theme of the 1st ACC, entitled “Advances and Challenges in Chemistry”, was carefully chosen to mark the 80th anniversary of opening of the School of Chemistry at Aristotle University of Thessaloniki, first established in 1943. This event will serve as a platform for researchers from all over the world to present the latest and most exciting research advances in different and distinct, but also overlap**, sub-specialities in the field of chemistry. Topics of interest include, but are not limited to:

  1. Advanced and Sustainable Synthetic Methodologies in Organic Chemistry
  2. Advances in Food Science, Technology and Quality Control
  3. Analytical Chemistry and Quality Control in Bioanalytical, Food, Environmental and Archaeometric applications
  4. Biochemistry, Clinical Biochemistry and Biotechnology
  5. Chemistry Education-Applications of Information and Communication Technologies in Chemistry
  6. Computational Chemistry and Molecular Modeling
  7. Environmental Chemistry and Technology
  8. Environmental pollutants: Analysis, Occurrence, Fate, Exposure Assessment and Treatment Approaches
  9. Experimental, Theoretical and Computational Physical Chemistry and Electrochemistry
  10. Green and Sustainable Chemistry and Chemical Technology
  11. Inorganic Chemistry—Bioinorganic Chemistry—Nanochemistry
  12. Organic Synthesis of Bioactive Molecules and Natural Products
  13. Polymer and Colors Chemistry and Technology

Prof. Dr. Thodoris Karapantsios
Prof. Dr. Victoria Samanidou
Dr. Fani Mantzouridou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inorganic chemistry
  • organic chemistry
  • biochemistry
  • quantum and computational chemistry
  • physical chemistry
  • analytical chemistry
  • environmental chemistry
  • chemistry education
  • chemical technology
  • polymer and color chemistry
  • food chemistry
  • advances
  • challenges
  • multidisciplinary science
  • interdisciplinary science

Published Papers (1 paper)

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Research

24 pages, 3838 KiB  
Article
Carbon Nanotube-Mediated Delivery of PTEN Variants: In Vitro Antitumor Activity in Breast Cancer Cells
by Rigini M. Papi, Konstantinos S. Tasioulis, Petros V. Kechagioglou, Maria A. Papaioannou, Eleftherios G. Andriotis and Dimitrios A. Kyriakidis
Molecules 2024, 29(12), 2785; https://doi.org/10.3390/molecules29122785 - 11 Jun 2024
Viewed by 555
Abstract
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a crucial tumor suppressor protein with frequent mutations and alterations. Although protein therapeutics are already integral to numerous medical fields, their potential remains nascent. This study aimed to investigate the impact of stable, [...] Read more.
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a crucial tumor suppressor protein with frequent mutations and alterations. Although protein therapeutics are already integral to numerous medical fields, their potential remains nascent. This study aimed to investigate the impact of stable, unphosphorylated recombinant human full-length PTEN and its truncated variants, regarding their tumor suppression activity with multiwalled-carbon nanotubes (MW-CNTs) as vehicles for their delivery in breast cancer cells (T-47D, ZR-75-1, and MCF-7). The cloning, overexpression, and purification of PTEN variants were achieved from E. coli, followed by successful binding to CNTs. Cell incubation with protein-functionalized CNTs revealed that the full-length PTEN-CNTs significantly inhibited cancer cell growth and stimulated apoptosis in ZR-75-1 and MCF-7 cells, while truncated PTEN fragments on CNTs had a lesser effect. The N-terminal fragment, despite possessing the active site, did not have the same effect as the full length PTEN, emphasizing the necessity of interaction with the C2 domain in the C-terminal tail. Our findings highlight the efficacy of full-length PTEN in inhibiting cancer growth and inducing apoptosis through the alteration of the expression levels of key apoptotic markers. In addition, the utilization of carbon nanotubes as a potent PTEN protein delivery system provides valuable insights for future applications in in vivo models and clinical studies. Full article
(This article belongs to the Special Issue Selected Papers from the 1st Aristotle Conference on Chemistry: Advances and Challenges in Chemistry)
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