Irreversible, Covalent, and Reversible Covalent approaches to Drug Discovery
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 4574
Special Issue Editors
Interests: medicinal chemistry; diagnostic tools; antimicrobial resistance; molecular modelling; drug design; supramolecular chemistry; physical organic chemistry
Interests: medicinal chemistry; biological chemistry; organic chemistry; molecular tools for drug development; rational drug design; poly(ADP-ribose) polymerases; sirtuins; viral macrodomain modulators; insulin-stimulated glucose uptake; Wnt/β-catenin inhibition; regenerative medicine
Special Issue Information
Dear Colleagues,
Over the past decade, researchers in medicinal chemistry have started to give increasing credence to the deliberate development of drug candidates that possess the ability to react with rather than interact with their intended drug targets. The key advantage of this approach lies in the ability of the drug to act only once and permanently affect the molecule of drug target being inhibited.
In previous decades such permanent modification was actively avoided. It was thought that off-target reaction events would lead to unintended modifications, potentially resulting in catastrophic adverse events. The progress made within recent years is down to the development of carefully selected “warheads”, units capable of high-precision interactions against the intended target while leaving a multitude of other biological macromolecules within a given patient unaffected.
This Special Issue of Molecules explores recent developments in this area in terms of new uses for existing warheads and also the development of novel warheads directed towards any area within the field of medicinal chemistry.
Dr. Mark Gray
Dr. Amit Nathubhai
Dr. Stephanie Myers
Guest Editors
Manuscript Submission Information
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Keywords
- Irreversible inhibitor
- Covalent inhibitor
- Reversible covalent inhibitor
- Mechanism-based inhibition
- Electrophilic drugs
- Drug warhead
