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Modern Trends in Bioactive Heterocyclic Chemistry

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 620

Special Issue Editor

Qiandongnan Engineering and Technology Research Center for Comprehensive Utilization of National Medicine, Kaili University, Kaili, China
Interests: pesticide synthesis; fungicide; natural product; organic synthesis; green pesticide
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Special Issue Information

Dear Colleagues,

The study of heterocycles, which is considered the most significant traditional branch of organic chemistry, plays a pivotal role in various sectors including pharmaceuticals, agrochemicals, veterinary medicine, and other related industries. Research interest in heterocyclic compounds is rapidly escalating due to their extensive synthetic investigation and functional versatility. This Special Issue of Molecules invites researchers to contribute original research papers or reviews in the fields of the design, synthesis, bioactivity, mechanism of action, and so on of heterocyclic compounds.

Dr. Pei Li
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at mdpi.longhoe.net by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heterocyclic chemistry
  • design
  • synthesis
  • bioactivity
  • mechanism of action

Published Papers (1 paper)

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Research

14 pages, 8025 KiB  
Article
Identification of 3-((4-Hydroxyphenyl)amino)propanoic Acid Derivatives as Anticancer Candidates with Promising Antioxidant Properties
by Povilas Kavaliauskas, Birutė Grybaitė, Birute Sapijanskaite-Banevič, Kazimieras Anusevičius, Ilona Jonuškienė, Rima Stankevičienė, Rūta Petraitienė, Vidmantas Petraitis, Ramunė Grigalevičiūtė, Edita Meškinytė, Rolandas Stankevičius and Vytautas Mickevičius
Molecules 2024, 29(13), 3125; https://doi.org/10.3390/molecules29133125 - 30 Jun 2024
Viewed by 524
Abstract
Various cancer-associated morbidities remain a growing global health challenge, resulting in a significant burden on healthcare systems worldwide due to high mortality rates and a frequent lack of novel therapeutic options for advanced and localized disease. Reactive oxygen species (ROS) play an important [...] Read more.
Various cancer-associated morbidities remain a growing global health challenge, resulting in a significant burden on healthcare systems worldwide due to high mortality rates and a frequent lack of novel therapeutic options for advanced and localized disease. Reactive oxygen species (ROS) play an important role in cancer pathogenesis and response to chemotherapeutics; therefore, it is crucial to develop novel compounds with both antioxidant and anticancer activity. In this study, a series of previously reported 3-((4-hydroxyphenyl)amino)propanoic acid derivatives (compounds 136) were evaluated for their anticancer and antioxidant activities. Compounds 12, 2022, and 29 were able to reduce A549 cell viability by 50% and suppress A549 cell migration in vitro. These compounds also showed favorable cytotoxicity properties towards noncancerous Vero cells. The most promising candidate, compound 20, exhibited potent antioxidant properties in the DPPH radical scavenging assay. These results demonstrate that 3-((4-hydroxyphenyl)amino)propanoic acid could be further explored as an attractive scaffold for the development of novel anticancer and antioxidant candidates. Full article
(This article belongs to the Special Issue Modern Trends in Bioactive Heterocyclic Chemistry)
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